Abstract
Biological signal transduction pathways control the essential functions in all cells and tissues. Understanding the mechanisms at the molecular level accelerates the development of new selective medicines. The determination of the disease related molecular targets is also essential in these efforts. Photoaffinity labeling provides a well-established technique for identification, localization of binding proteins, and studying intracellular protein-protein interactions. The application of photoaffinity labeling in biological signal transduction is discussed and illustrated with a rich collection of specific examples.
Keywords
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This paper is dedicated to Prof. Glenn D. Prestwich (University of Utah) on the occasion of his 50th birthday.
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Dormán, G. (2000). Photoaffinity Labeling in Biological Signal Transduction. In: Waldmann, H. (eds) Bioorganic Chemistry of Biological Signal Transduction. Topics in Current Chemistry, vol 211. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-45035-1_6
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