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Functional Micro-imaging at the Interface of Bone Mechanics and Biology

  • Chapter
Mechanics of Biological Tissue

8 Conclusions

Micro-architectural bone imaging is a nondestructive, non-invasive, and precise procedure that allows the measurement of trabecular and compact bone as well as the repetitive 3D assessment and computation of microstructural and micromechanical properties in patients. The procedure can help improve predictions of fracture risk, clarify the pathophysiology of skeletal diseases, and define the response to therapy. Hierarchical bioimaging in combination with biocomputational approaches are well suited for investigating structurefunction relationships as well as failure mechanisms in normal, osteoporotic and treated bone. We expect these findings to improve our understanding of the influence of densitometric, morphological but also loading factors in the etiology of spontaneous fractures of the hip and the spine. Eventually, this improved understanding may lead to more successful approaches in the prevention of such age- and disease-related fractures.

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Authors and Affiliations

  1. Institute for Biomedical Engineering, Swiss Federal Institute of Technology (ETH) and University of Zürich, Switzerland

    R. Müller, A. Nazarian, P. Schneider, M. Stauber, P. Thurner, G. H. van Lenthe & R. Voide

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  1. R. Müller
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  2. A. Nazarian
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  3. P. Schneider
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  4. M. Stauber
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  5. P. Thurner
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  6. G. H. van Lenthe
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  7. R. Voide
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Editors and Affiliations

  1. Institute for Structural Analysis, Computational Biomechanics, Graz University of Technology, Schiesstattgasse 14-B, 8010, Graz, Austria

    Gerhard A. Holzapfel

  2. Department of Mathematics, University Gardens, University of Glasgow, Glasgow, G12 8QW, Scotland, UK

    Ray W. Ogden

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© 2006 Springer-Verlag Berlin Heidelberg

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Müller, R. et al. (2006). Functional Micro-imaging at the Interface of Bone Mechanics and Biology. In: Holzapfel, G.A., Ogden, R.W. (eds) Mechanics of Biological Tissue. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-31184-X_34

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  • DOI: https://doi.org/10.1007/3-540-31184-X_34

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-25194-1

  • Online ISBN: 978-3-540-31184-3

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