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Dry Skin

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References

  1. Akimoto K, Yoshikawa N, Higaki Y, Kawashima M, Imokawa G (1993) Quantitative analysis of stratum corneum lipids in xerosis and asteatotic eczema. J Dermatol 20:1–6

    CAS  PubMed  Google Scholar 

  2. Appa Y (1999) Retinoid therapy: compatible skin care. Skin Pharmacol Appl Skin Physiol 12:111–119

    Article  CAS  PubMed  Google Scholar 

  3. Arikawa J, Ishibashi M, Kawashima M, Takagi Y, Ichikawa Y, Imokawa G (2002) Decreased levels of sphingosine, a natural antimicrobial agent, may be associated with vulnerability of the stratum corneum from patients with atopic dermatitis to colonization by Staphylococcus aureus. J Invest Dermatol 119:433–439

    Article  CAS  PubMed  Google Scholar 

  4. Bhawan J, Andersen W, Lee J, Labadie R, Solares G (1995) Photoaging versus intrinsic aging: a morphologic assessment of facial skin. J Cutan Pathol 22:154–159

    CAS  PubMed  Google Scholar 

  5. Bleck O, Abeck D, Ring J, Hoppe U, Vietzke JP, Wolber R, Brandt O, Schreiner V (1999) Two ceramide subfractions detectable in Cer(AS) position by HPTLC in skin surface lipids of non-lesional skin of atopic eczema. J Invest Dermatol 113:894–900

    Article  CAS  PubMed  Google Scholar 

  6. Bouwstra JA, Honeywell-Nguyen PL, Gooris GS, Ponec M (2003) Structure of the skin barrier and its modulation by vesicular formulations. Prog Lipid Res 42:1–36

    CAS  PubMed  Google Scholar 

  7. Choi EH, Kim MJ, Ahn SK, Park WS, Son ED, Nam GW, Chang I, Lee SH (2002) The skin barrier of aged hairless mice in a dry environment. Br J Dermatol 147:244–249

    Article  CAS  PubMed  Google Scholar 

  8. Conti A, Roges J, Verdejo P, Harding CR, Rawlings AV (1996) Seasonal influences on stratumcorneum ceramides 1 fatty acids and the influence of topical essential fatty acids. Int J Cosm Sci 18:1–12

    CAS  Google Scholar 

  9. Denda M, Sato J, Tsuchiya T, Elias PM, Feingold KR (1998) Low humidity stimulates epidermal DNA synthesis and amplifies the hyperproliferative response to barrier disruption: implication for seasonal exacerbations of inflammatory dermatosis. J Invest Dermatol 111:873–878

    CAS  PubMed  Google Scholar 

  10. Di Nardo A, Wertz PW, Gianetti A, Seidenari S (1998) Ceramide and cholesterol composition of the skin of patients with atopic dermatitis. Acta Derm Venereol 78:27–30

    PubMed  Google Scholar 

  11. Elias PM, Ghadially R (2002) The aged epidermal permeability barrier: basis for functional abnormalities. Clin Geriatr Med 18:103–120

    Article  PubMed  Google Scholar 

  12. Engelke M, Jensen JM, Ekanayake-Mudiyanselage S, Proksch E (1997) Effects of xerosis and ageing on epidermal proliferation and differentiation. Br J Dermatol 137: 219–225

    Article  CAS  PubMed  Google Scholar 

  13. Fartasch M, Bassukas ID, Diepgen TL (1992) Disturbed extruding mechanism of lamellar bodies in dry noneczematous skin of atopics. Br J Dermatol 127:221–227

    CAS  PubMed  Google Scholar 

  14. Fartasch M (1995) Human barrier formation and reaction to irritation. Curr Probl Dermatol 23:95–103

    CAS  PubMed  Google Scholar 

  15. Feingold KR, Elias PM (2000) The environmental interface: regulation of permeability barrier homeostasis. In: Lodén M, Maibach HI (Eds) Dry skin and moisturizers. CRC Press, Boca Raton, pp 45–58

    Google Scholar 

  16. Ghadially R, Brown BE, Sequeria-Martin SM, Feingold KR, Elias PM (1995) The aged epidermal permeability barrier. J Clin Invest 95:2281–2290

    CAS  PubMed  Google Scholar 

  17. Ghadially R, Brown BE, Hanley K, Reed JT, Feingold KR, Elias PM (1996) Decreased epidermal lipid synthesis accounts for altered/barrier function in aged mice. J Invest Dermatol 106:1064–1069

    Article  CAS  PubMed  Google Scholar 

  18. Ghadially R (1998) Aging and the epidermal permeability barrier. Am J Contact Derm 9:162–169

    CAS  Google Scholar 

  19. Hara J, Higuchi K, Okamoto R, Kawashima M, Imokawa G (2000) High-expression of sphingomyelinase deacylase is an important determinant of ceramide deficiency leading to barrier disruption atopic dermatitis. J Invest Dermatol 115:406–413

    Article  CAS  PubMed  Google Scholar 

  20. Hirschmann JV, Raugi GJ (1999) Adult scurvy. J Am Acad Dermatol 41:895–906

    Article  CAS  PubMed  Google Scholar 

  21. Höltje M, Förster T, Brandt B, Engelss T, von Rybinski W, Hölje HD (2001) Molecular dynamics simulations of stratum corneum lipid models: fatty acids and cholesterol. Biochim Biophys Acta 1511:156–167

    PubMed  Google Scholar 

  22. Horii I, Nakayama Y, Obata M, Tagami H (1989) Stratum corneum hydration and amino acid content in xerotic skin. Br J Dermatol 121:587–592

    CAS  PubMed  Google Scholar 

  23. Imokawa G, Akasaki S, Minematsu Y, Kawai M (1989) Importance of intercellular lipids in water-retention properties of the stratum corneum: induction and recovery study of surfactant dry skin. Arch Dermatol Res 281:45–51

    Article  CAS  PubMed  Google Scholar 

  24. Imokawa G, Abe A, Jin K, Higaki Y, Kawashima M, Hidano A (1991) Decreased level of ceramides in stratum corneum of atopic dermatitis: an etiologic factor in atopic dry skin? J Invest Dermatol 96:523–536

    CAS  PubMed  Google Scholar 

  25. Jin K, higaki Y, Tagaki Y, Higuchi K, Yada Y, Kawashima M, Imokawa G (1994) Analysis of beta-glucocerebrosidase and ceramidase activities in atopic and aged dry skin. Acta Derm Venereol 74:337–340

    CAS  PubMed  Google Scholar 

  26. Katagiri C, Sato J, Nomura J, Denda M (2003) Changes in environmental humidity affect the water-holding property of the stratum corneum and its free amino acid content, and the expression of filaggrin in the epidermis of hairless mice. J Dermatol Sci 31:29–35

    Article  CAS  PubMed  Google Scholar 

  27. Lee SH, Elias PM, Proksch E, Menon GK, Mao-Quiang M, Feingold KR (1992) Calcium and potassium are important regulators of barrier homeostasis in murine epidermis. J Clin Invest 89:530–538

    CAS  PubMed  Google Scholar 

  28. Macheleidt O, Kaiser HW, Sandhoff K (2002) Deficiency of epidermal protein-bound w-hydroxyceramides in atopic dermatitis. J Invest Dermatol 119:166–173

    Article  CAS  PubMed  Google Scholar 

  29. Matsumoto M, Umemoto N, Sufiura H, Uehara M (1999) Difference in ceramides composition between “dry” and “normal” skin in patients with atopic dermatitis. Acta Derm Venereol 79:246–247

    CAS  PubMed  Google Scholar 

  30. Meguro S, Arai Y, Masukawa Y, Uie K, Tokimitsu I (2000) Relationship between covalently bound ceramides and transepidermal water loss. Arch Dermatol Res 292:463–468

    Article  CAS  PubMed  Google Scholar 

  31. Melnik B, Hollmann J, Plewig G (1988) Decreased stratum corneum ceramides in atopic individuals-a pathobiochemical factor in xerosis? Br J Dermatol 119:547–549

    CAS  PubMed  Google Scholar 

  32. Menon GK (2002) New insights into skin structure: scratching the surface. Adv Drug del Rev 54:S3–S17

    CAS  Google Scholar 

  33. Miyauchi H, Horio T, Asada Y (1992) The effect of ultraviolet radiation on the water-reservoir functions of the stratum corneum. Photodermatol Photoimmunol Photomed 9:193–197

    CAS  PubMed  Google Scholar 

  34. Motta S, Monti M, Sesana S, Mellesi L, Ghidoni R, Caputo R (1994) Abnormality of water barrier function in psoriasis. Arch Dermatol 130:452–456

    Article  CAS  PubMed  Google Scholar 

  35. Murata Y, Ogata J, Higaki Y, Kawashima M, Yada Y, Higuchi K, Tsuchiya T, Kawainami S, Imokawa G (1996) Abnormal expression of sphingomyelin acylase in atopic dermatitis: an etiologic factor for ceramide deficiency? J Invest Dermatol 106:1242–1249

    Article  CAS  PubMed  Google Scholar 

  36. Nickoloff BJ, Naidu Y (1994) Perturbation of epidermal barrier function correlates with irritation of cytokine cascade in human skin. J Am Acad Dermatol 30:535–546

    CAS  PubMed  Google Scholar 

  37. O’goshi K, Iguchi M, Tagami H (2000) Functional analysis of the stratum corneum of scalp skin: studies in patients with alopecia areata and androgenic alopecia. Arch Dermatol Res 292:605–611

    CAS  PubMed  Google Scholar 

  38. Okamoto R, Arikawa J, Ishibashi M, Kawasjima M, Takagi Y, Imokawa G (2003) Sphingosylphosphorylcholine is upregulated in the stratum corneum of patients with atopic dermatitis. J Lipid Res 44:93–102

    CAS  PubMed  Google Scholar 

  39. Park TH, Park CH, Nha SK, Lee SH, Song KS, Lee HY, Han DS (1995) Dry skin in patients undergoing maintenance haemodialysis: the role of decreased sweating of the eccrine sweat gland. Nephrol Dial Transplant 10:2269–2273

    CAS  PubMed  Google Scholar 

  40. Pilgram GS, Vissers DC, van der Meulen H, Pavel S, Lavrijsen SP, Bouwstra JA, Koerten HK (2001) Aberrant lipid organization in stratum corneum of patients with atopic dermatitis and lamellar ichthyosis. J Invest Dermatol 117:710–717

    Article  CAS  PubMed  Google Scholar 

  41. Plewig G, Jansen T, Schürer NY (1997) Das Stratum corneum. Hautarzt 48:510–521

    Article  CAS  PubMed  Google Scholar 

  42. Proksch E, Feingold KR, Mao-Qiang M, Elias PM (1991) Barrier function regulates epidermal DNA synthesis. J Clin Invest 87:1668–1673

    CAS  PubMed  Google Scholar 

  43. Rawlings AV, Scott IR, Harding CG, Bowser PA (1994) Stratum corneum moisturizing at the molecular level. J Invest Dermatol 103:731–740

    Article  CAS  PubMed  Google Scholar 

  44. Redmond GP (2002) Hypothyroidism and women’s health. Int J Fertil Womens Med 47:123–127

    PubMed  Google Scholar 

  45. Rogers J, Mayo A, Wathinson A et al (1993) Stratum corneum lipids: the effect of aging and the seasons. Arch Dermatol Res 288:765–770

    Google Scholar 

  46. Rogers J, Harding C, Mayo A, Banks J, Rawlings A (1996) Skin dryness-what is it? J Invest Dermatol 100:510A

    Google Scholar 

  47. Rowe A, Mallon E, Rosenberger P, Barrett M, Walsh J, Bunker CB (1999) Depletion of cutaneous peptidergic innervation in HIV-associated xerosis. J Invest Dermatol 112:284–289

    Article  CAS  PubMed  Google Scholar 

  48. Saint-Leger D, Francois AM, Leveque JL, Stoudemayer TJ, Kligman AM, Grove G (1989) Stratum corneum lipids in skin xerosis. Dermatologica 178:151–155

    CAS  PubMed  Google Scholar 

  49. Sakai S, Endo Y, Ozawa N, Suguwara T, Kusaka A, Sayo T, Tagami H, Inoue S (2003) Characteristics of the epidermis and stratum corneum of hairless mice with experimentally induced diabetes mellitus. J Invest Dermatol 120:79–85

    Article  CAS  PubMed  Google Scholar 

  50. Sato J, Denda D, Nakanishi J, Nomura J (1998) Cholesterol sulfate inhibits proteases that are involved in desquamation of stratum corneum. J Invest Dermatol 111:189A

    Google Scholar 

  51. Sato J, Denda D, Chang S, Elisa PM, Feingold KR (2002) Abrupt decreases in environmental humidity induce abnormalities in permeability barrier homeostasis. J Invest Dermatol 119:900–904

    CAS  PubMed  Google Scholar 

  52. Sator PG, Schmidt JB, Honigsmann H (2003) Comparison of epidermal hydration and skin surface lipids in healthy individuals and in patients with atopic dermatitis. J Am Acad Dermatol 48:352–328

    Article  PubMed  Google Scholar 

  53. Seki T, Morimatsu S, Nagahori H, Morohashi M (2003) Free residual chlorine in bathing water reduces the waterholding capacity of the stratum corneum in atopic skin. Dermatol 30:196–202

    Google Scholar 

  54. Schaefer L, Kragballe K (1991) Abnormalities in epidermal lipid metabolism in patients with atopic dermatitis. J Invest Dermatol 96:10–15

    Google Scholar 

  55. Schreiner V, Gooris GS, Pfeiffer S, Lanzendörfer G, Wenck H, Diembeck W, Proksch E, Bouwstra J (2000) Barrier characteristics of different human skin types investigated with x-ray diffraction, lipid analysis, and electron microscopy imaging. J Invest Dermatol 114:654–660

    Article  CAS  PubMed  Google Scholar 

  56. Schürer NY, Elias PM (1991) The biochemistry and function of stratum corneum lipids. Adv Lipid Res 24:27–56

    PubMed  Google Scholar 

  57. Schürer NY, Buck H, Schwanitz HJ, Lüttje D (2002) Hautbesonderheiten bei Hochbetagten. Geriatrie J 11:25–29

    Google Scholar 

  58. Simon M, Bernard D, Minondo AM, Camus C, Fiat F, Corcuff P, Schmidt R, Serre G (2001) Persistence of both peripheral and non-peripheral corneodesmosomes in the upper stratum corneum of winter xerosis skin versus only peripheral in normal skin. J Invest Dermatol 116: 23–30

    Article  CAS  PubMed  Google Scholar 

  59. Sondell B, Thornell L-E, Egelrud T (1995) Evidence that stratum corneum chymotryptic enzyme is transported to the stratum corneum extracellular space via lamellar bodies. J Invest Dermatol 104:819A

    Article  Google Scholar 

  60. Smith DR, Sheu HM, Hsieh FS, Lee YL, Chang SJ, Guo YL (2002) Prevalence of skin disease among nursing home patients in southern Taiwan. Int J Dermatol 41:754–759

    Article  PubMed  Google Scholar 

  61. Steinert PM (2000) The complexity and redundancy of epithelial barrier function. J Cell Biol 151:5–7

    Article  Google Scholar 

  62. Stewart ME, Downing DT (2001) The ω-hydroxyceramides of pig epidermis are attached to corneocytes solely through ω-hydroxyl groups. J Lipid Res 42:1105–1110

    CAS  PubMed  Google Scholar 

  63. Strumia R, Varotti E, Manzato E, Gualandi M (2001) Skin signs in anorexia nervosa. Dermatology 203:314–317

    CAS  PubMed  Google Scholar 

  64. Suzuki Y, Nomura J, Koyama J, Takahishi M, Horii I (1994) Detection and characterization of endogenous protease associated with desquamation of stratum corneum. Arch Dermatol Res 285:372–377

    Google Scholar 

  65. Tagami H, Kobayashi H, Zhen X-S, Kikuchi K (2001) Environmental effects on the functions of the stratum corneum. J Invest Dermatol 6:87–94

    CAS  Google Scholar 

  66. Tanno O, Ota Y, Kitamura N, Katsube T, Inoue S (2000) Nicotinamide increases biosynthesis of ceramides as well as other stratum corneum lipids to improve the epidermal permeability barrier. Br J Dermatol 143:524–531

    Article  CAS  PubMed  Google Scholar 

  67. Tezuka T, Qing J, Saheki M, Kusuda S, Takahashi M (1994) Terminal differentiation of facial epidermis of the aged: immunohistochemical studies. Dermatology 188:21–24

    CAS  PubMed  Google Scholar 

  68. Thiele JJ, Dreher F, Elsner P (2001) Antioxidant defense systems in skin. In: Elsner P, Maibach HI (eds) Cosmeceuticals. pp 145–188

    Google Scholar 

  69. Uter W, Gefeller O, Schwanitz H (1998) An epidemiological study of the influence of season (cold and dry air) on the occurrence of irritant skin changes of the hand. Br J Dermatol 138:266–267

    Article  CAS  PubMed  Google Scholar 

  70. Wertz PS, Madison KC, Downing DT (1989) Covalently bound lipids of human stratum corneum and from comedones. J Invest Dermatol 92:109–111

    CAS  PubMed  Google Scholar 

  71. Wilhelm KP (1996) Prevention of surfactant-induced irritant contact dermatitis. Curr Probl Dermatol 25:78–85

    CAS  PubMed  Google Scholar 

  72. Wertz PW, Cho ES, Downing DT (1983) Effect of essential fatty acid deficiency on the epidermal sphingolipids of the rat. Biochim Biophys Acta 753:350–355

    CAS  PubMed  Google Scholar 

  73. Yoon HS, Baik SH, Oh CH (2002) Quantitative measurement of desquamation and skin elasticity in diabetic patients. Skin Res Technol 8:250–254

    Article  PubMed  Google Scholar 

  74. Zhen Y-X, Suetake T, Tagami H (1999) Number of cell layers of the stratum corneum in normal skin in relationship to the anatomical location of the body, age, sex, and physical parameters. Arch Dermatol Res 291:555–559

    Google Scholar 

  75. Zouboulis CC, Seltmann H, Hiroi N, Chen W, Young M, Oeff M, Scherbaum WA, Orfanos CE, McCann SM, Bornstein SR (2002) Corticotropin-releasing hormone: an autocrine hormone that promotes lipogenesis in human sebocyte. Proc Natl Acad Sci U S A 99:7148–7153

    Article  CAS  PubMed  Google Scholar 

  76. Zouboulis CC, Boschnakow A (2001) Chronological ageing and photoageing of the human sebaceous gland. Clin Exp Dermatol. 26:600–607

    Article  CAS  PubMed  Google Scholar 

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Schürer, N. (2006). Dry Skin. In: Ring, J., Przybilla, B., Ruzicka, T. (eds) Handbook of Atopic Eczema. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-29856-8_15

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