Abstract
This article describes polymers which are blood-compatible not by the addition of anticoagulants or due to the formation of neointima, but because they consist of antithrombogenic biomaterial that does not include blood-soluble additives either. Since research in this area is still in its infancy, the author has placed the emphasis on his own experimental results.
Preview
Unable to display preview. Download preview PDF.
Abbreviations
- AAm:
-
acrylamide
- HEMA:
-
2-hydroxyethyl methacrylate
- MMA:
-
methyl methacrylate
- N-VP:
-
N-vinyl pyrrolidone
- DMAEM:
-
2-(N, N-dimethylamino)ethyl methacrylate
- AA:
-
acrylic acid
- AANa:
-
sodium acrylate
- PAAm:
-
polyacrylamide
- PVA:
-
poly(vinyl alcohol)
- PAA:
-
poly(acrylic acid)
- PE:
-
polyethylene
- HDPE:
-
high-density polyethylene
- LDPE:
-
low-density polyethylene
- PP:
-
polypropylene
- PHEMA:
-
poly(2-hydroxyethyl methacrylate)
- PMMA:
-
poly(methyl methacrylate)
- PET:
-
poly(ethylene terephthalate)
- PTFE:
-
polytetrafluoroethylene
- VAECO:
-
vinyl alcohol-ethylene copolymer
- BSA:
-
bovine serum albumin
- PRP:
-
platelet-rich plasma
- AIVC:
-
4,4′-azobis-4-cyanovaloyl chloride
- TMPO:
-
2,2,6,6-tetramethyl-4-aminopiperidine-1-oxyl
- ESR:
-
electron spin resonance
- XPS:
-
X-ray photoelectron spectroscopy
- ESCA:
-
electron spectroscopy for chemical analysis
- SEM:
-
scanning electron microscopy
9 References
Ulrich, H., Bonk, H. W., Colovos, G. C.: Synthetic Biomedical Polymers; Szycher, M., Robinson, W. J. (Ed.) Technomic Publ. Co., Connecticut, p. 29, 1980
Ratner, B. D.: Photon, Electron, and Ion Probes of Polymer Structure and Properties; Dwight, D. W., Fabish, T. J., Thomas, H. R. (Eds.) ACS Symp. Series 162, 371 (1981)
Costa, V. S. D., Brier-Russel, D., Salzman, E. W., Merrill, E. W.: J. Colloid Interface Sci. 80, 445 (1981)
Chawla, A. S.: J. Biomed. Mater. Res. 16, 501 (1982)
Graham, S. W., Hercules, D. M.: J. Biomed. Mater. Res. 15, 349 (1981)
Matsumoto, H., Kimura, T., Takamatsu, T., Fukada, E.: Jinkozoki 5, 152 (1976)
Andrade, J. D. (Ed.) Hydrogels for Medical and Related Applications, ACS Symp. Series 31, 1976
Wichterle, O., Lim, D.: Nature 185, 117 (1960)
Iwamoto, G. K., King, R. N., Andrade, J. D.: Photon, Electron, and Ion Probes of Polymer Structure and Properties; Dwight, D. W., Fabish, T. J., Thomas, H. R. (Eds.) ACS Symp. Series 162, 405 (1981)
Nosé, Y., Tajima, K., Imai, Y., Klain, M., Mrava, G., Schriber, K., Urbanek, K., Ogawa, H.: Trans. Am. Soc. Artif. Intern. Organs 17, 482 (1971)
Salzman, E. W., Lindon, J., Brier, D., Merrill, E. W.: Ann. N.Y. Acad. Sci. 283 114 (1977)
Bair, R. E., Akers, C. K.: Trans. Am. Soc. Artif. Intern. Organs 27, 770 (1978)
Ward, R. S., Tsuchiyama, B. J., O'Connor, K. A.: Trans. Am. Soc. Artif. Intern. Organs 27, 410 (1980)
Hecher, J. F., Edwards, R. O.: J. Biomed. Mater. Res. 15, 1 (1981)
Bair, R. E., Gott, V. L., Feruse, A.: Trans. Am. Soc. Artif. Intern. Organs 16, 50 (1970)
Schrader, M. D.: J. Colloid Interface Sci. 88, 296 (1982)
Andrade, J. D.: Med. Instrum. 7, 110 (1973)
Coleman, D. L., Gregonis, D. E., Andrade, J. D.: J. Biomed. Mater. Res. 16, 381 (1982)
Ratner, B. D., Hoffman, A. S., Hanson, S. R., Harker, L. A., Whiffew, J. D.: J. Polym. Sci., Polym. Symp. 66, 363 (1979)
Hanson, S. R., Harker, L. A., Ratner, B. D., Hoffman, A. S.: J. Lab. Clin. Med. 95, 289 (1980)
Mahmud, N. A., Wan, S., Sa da Costa, V., Vitale, V., Brier-Russell, D., Kuchner, L., Salzman, E. W., and Merrill, E. W.: Physicochemical Aspects of Polymer Surfaces, Vol. 2; Mittal, K. L. (Ed.) Plenum Press, New York, p. 953, 1983
Sawyer, P. N., Srinivasan, S.: Am. J. Surg. 114, 42 (1967)
Bruck, S. D.: Nature 243, 416 (1973)
Okano, T. Nishiyama, S., Shinohara, I., Akaike, T., Sakurai, Y., Kataoka, K., Tsuruta, T.: J. Biomed. Mater. Res. 15, 393 (1981)
Kim, S. W., Lee, E. S.: J. Polym. Sci., Polym. Symp. 66, 429 (1979)
Vroman, L., Leonard, E. F. (Eds.): The Behavior of Blood and its Components at Interfaces, Ann. N.Y. Aca. Sci. 283, (1977)
Bruck, S. D.: J. Polym. Sci., Polym. Symp. 66, 283 (1979)
Salzman, E. W. (Ed.): Interaction of the Blood with Natural and Artificial Surfaces, Marcel Dekker, Inc. New York and Basel, 1981
Biomaterials: Interfacial Phenomena and Applications, ACS Adv. Chem. 199, 1982
Bantijes, A.: British Polym. J. 10, 267 (1978)
Griffin, J. H., Cochrane, C. G.: Semin. Thromb. Hemostasis 5, 254 (1974)
Vroman, L., Adams, A. L.: J. Biomed. Mater. Res. 3, 43 (1969)
Hoffman, A. S.: ACS Organic Coatings and Applied Polymer Science Proceedings, 48, 28 (1983)
Ikada, Y., Suzuki, M., Tamada, Y.: ACS Polymer Preprints, 24(1) (1983)
van Oss, C. J.: Ann. Rev. Microbiol. 32, 19 (1978)
Absolom, D. R., Francis, D. E., Zingg, W., van Oss, C. J., Neuman, A. W.: J. Coll. Interface Sci. 85, 168 (1982)
Gerson, D. F., Scheer, D.: Biochem. Biophys. Acta, 602, 506 (1980)
Dexter, S. C.: J. Coll. Interface Sci. 70, 346 (1979)
Cherry, B. W.: Polymer Surfaces, Cambridge Univ. Press 1981
Fowkes, F. M.: J. Phys. Chem. 66, 382 (1962); 67, 2538 (1963); ACS Adv. Chem. 43, 99 (1964); Ind. Eng. Chem. 56, No. 12, 40 (1964)
Ikada, Y., Matsunaga, T.: J. Adhesion Soc. Japan 15, 91 (1979)
Owens, D. K., Wendt, R. C.: J. Appl. Polym. Sci.: 13, 1741 (1969)
Andrews, R. H., Kinloch, A. J.: Proc. Roy. Soc. London A 332, 385 (1973)
Lelah, M. D., Stafford, R. J., Lambrecht, L. K., Young, B. R., Cooper, S. L.: Trans. Am. Soc. Artif. Intern. Organs 27, 504 (1981)
Matsunaga, T., Ikada, Y.: J. Colloid Interface Sci. 84, 8 (1981)
Yano, U., Komai, T., Kawasaki, T., Hujiwara, Y.: Prep. Japan Soc. Biomater. 2, 45 (1980)
Paul, L., Sharma, C. P.: J. Colloid Interface Sci. 84, 546 (1981)
Bornzin, G. A., Miller, I. F.: J. Colloid Interface Sci. 86, 539 (1982)
Fowkes, F. M., Mostafa, M. A.: Ind. Eng. Chem. Prod. Res. Dev. 17, 3 (1978)
Sello, S. B., Stevens, C. V.: Pure & Appl. Chem. 53, 2211 (1981)
Grinnell, F.: Intern. Rev. Cytology 53, 65 (1979)
Kronick, P. L.: Synthetic Biomedical Polymers; Szycher, M., Robinson, W. J. (Eds.) Technomic Publ. Co., Connecticut, p. 153, 1980
Ratner, B. D.: J. Biomed. Mater. Res. 14, 665 (1980)
Ikada, Y., Iwata, H., Mita, T., Nagaoka, S.: J. Biomed. Mater. Res. 13, 607 (1979)
Taniguchi, M., Samal, R. K., Suzuki, M., Iwata, H., Ikada, Y.: Graft Copolymerization of Lignocellulosic Fibers; Hon, D. N.-S (Ed.) ACS Symp. Series 187, 217 (1982)
Ikada, Y., Lonikar, S. V., Ham, M.-S., Tamada, Y.: Polym. Prep. Japan 31, 1785 (1982)
Samal, R. K., Iwata, H., Ikada, Y.: Physicochemical Aspects of Polymer Surfaces: Mittal, K. L. (Ed.) Plenum, New York, Vol. 2, 801, 1983
Fischer, J. P., Becker, U., Halasz, S.-P., Mück, K.-F., Püschner, H., Rösinger, S., Schmidt, A., Suhr, H. H.: J. Polym. Sci. Polym. Sym. 66, 443 (1979)
Hoffman, A. S.: Radiat. Phys. Chem. 18, 323 (1981)
Ellinghorst, G., Jansen, B.: Radiat. Phys. Chem. 18, 1111 (1981)
Chapiro, A., Domurado, D., Foex-Millequant, M., Jendrychowska-Bonamour, A. M.: Radiat. Phys. Chem. 18, 1200 (1981)
Hayashi, K., Murata, K., Yamamoto, J., Yamashita, I.: Prep. Annual Meeting, Japan Soc. Biomater. 4, 115 (1982)
Ikada, Y., Suzuki, M., Taniguchi, M., Iwata, H., Taki, W., Miyake, H., Yonekawa, Y., Handa, H.: Radiat. Phys. Chem. 18, 1207 (1981)
Suzuki, M., Tamada, Y., Iwata, H., Ikada, Y.: Physicochemical Aspects of Polymer Surfaces; Mittal, K. L. (Ed.) Plenum, New York, Vol. 2, 923 (1983)
H. V. Boenig, Plasma Science and Technology, Cornell Univ. Press, Ithaca and London, 1982
Fales, J. D., Bradley, A., Howe, R. E.: Vacuum Technology, March, 53 (1976)
Kronick, P.: contract No. NIH-NO1-HV-1-2017, Annual Report, July 1976
Suzuki, M., Piao, D.-S., Ikada, Y.: Polym. Prep. Japan 31, 286 (1982)
Andrade, J. D., King, R. N., Gregonis, D. E.: Hydrogels for Medical and Related Applications; Andrade, J. D. (Ed.) ACS Symp. Series 31, 206 (1976)
Benes, P., Paulenova, M.: Colloid and Polym. Sci. 251, 766 (1973)
Van Wagenen, R. A., Coleman, D. L., King, R. N., Trioro, P., Brostrom, L., Smith, L. M., Gregonis, D. E., Andrade, J. D.: J. Colloid Interface Sci. 84, 155 (1981)
Ikada, Y., Iwata, H., Horii, F., Matsunaga, T., Taniguchi, M., Suzuki, M., Taki, W., Yamagata, S., Yonekawa, Y., Handa, H.: J. Biomed. Mater. Res. 15, 697 (1981)
Yoshizaki, O.: Kobunshi Kagaku 12, 414 (1955)
Ratner, B. D., Weathersby, P. K., Hoffman, A. S., Kelly, M. A., Scharpen, L. H.: J. Appl. Polym. Sci. 22, 643 (1978)
Popov, K. N., Degterev, I. A., Zaikov, G. Ye.: Polym. Sci. U.S.S.R. 22, 1790 (1980)
Hermans, J.: J. Chem. Phys. 77, 2193 (1982)
Ikada, Y., Suzuki, M., Tamada, Y.: Prep. Regional Meeting of The Chemical Society of Japan (Chubu) 13, 104 (1982)
Hughes, R. C., Pena, S. D., Clark, J., Dourmashkin, R. R.: Exp. Cell. Res. 121, 307 (1979)
Komai, T., Nosé, Y.: Jinkozoki 4, 114 (1975)
Miyake, H., Taki, W., Yonekawa, Y., Handa, H., Suzuki, M., Ikada, Y.: Presented at Annual Meeting of Vascular Syst., Soc. Japan. Gifu, Nov. 23, 1982
Yamagata, S., Handa, H., Taki, W., Yonekawa, Y., Ikada, Y., Iwata, H.: J. Microsurgery 1, 208 (1979)
Pierce, W. S.: Polymers in Medicine and Surgery: Kronenthal, R. L., Oser, Z., Martin, E. (Eds.) Polymer Sci. Technology, Vol. 8, 263, 1975
Annis, D.: British Polym. J. 10, 238 (1978)
Matsuda, T., Akutsu, T.: ACS Organic Coatings and Applied Polymer Science Proceedings, 48, 647 (1983)
Moncada, S., Gryglewski, R., Bunting, S., Vane, J. R.: Nature 263, 663 (1976)
Porath, J.: Biochem. Soc. Trans. 7, 1197 (1979)
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 1984 Springer-Verlag
About this paper
Cite this paper
Ikada, Y. (1984). Blood-compatible polymers. In: Polymers in Medicine. Advances in Polymer Science, vol 57. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-12796-8_11
Download citation
DOI: https://doi.org/10.1007/3-540-12796-8_11
Received:
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-12796-3
Online ISBN: 978-3-540-38740-4
eBook Packages: Springer Book Archive