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Sizing, Shaping and Pharmaceutical Applications of Polyelectrolyte Complex Nanoparticles

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Book cover Polyelectrolyte Complexes in the Dispersed and Solid State II

Part of the book series: Advances in Polymer Science ((POLYMER,volume 256))

Abstract

This contribution reviews polyelectrolyte (PEL) complex (PEC) nanoparticles prepared by mixing solutions of oppositely charged PELs, with special focus on the regulation of their size and shape by PEL structural and media parameters and on their pharmaceutical applications. Experimental and simulation evidence indicates that salt and PEL concentration, pH, mixing ratio and order, PEL molecular weight and topology are useful parameters for regulation of the size and internal structure of spherical PEC nanoparticles. Experimental and theoretical data are presented to show that PEL flexibility and stiffness are able to influence and even control PEC nanoparticle shape. Finally, the options, advantages, and challenges of dispersed PEC particles for pharmaceutical applications are outlined, emphasizing the uptake and release properties towards proteins and drugs and the interaction of these nanoparticles with cells.

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Acknowledgements

Concepts and experimental work outlined and shown in this review are partly related to the Special Research Area/Transregional 79 (TRR 79, part project M7) entitled “Materials for Tissue Regeneration in Systemically Diseased Bones” by Deutsche Forschungsgemeinschaft (DFG) involving universities and research institutes in Giessen, Heidelberg and Dresden, Germany.

 DRESDEN concept linking research activities of IPF Dresden and TU Dresden is gratefully acknowledged.

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  1. Department of Polyelectrolytes and Dispersions, Leibniz-Institut für Polymerforschung (IPF) Dresden e.V., Hohe Strasse 6, 01069, Dresden, Germany

    M. Müller

  2. Fachrichtung Chemie und Lebensmittelchemie, Technische Universität Dresden (TUD), 01062, Dresden, Germany

    M. Müller

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  1. Department of Polyelectrolytes and Dispersions, Leibniz Institute of Polymer Research Dresden, Dresden, Germany

    Martin Müller

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Müller, M. (2012). Sizing, Shaping and Pharmaceutical Applications of Polyelectrolyte Complex Nanoparticles. In: Müller, M. (eds) Polyelectrolyte Complexes in the Dispersed and Solid State II. Advances in Polymer Science, vol 256. Springer, Berlin, Heidelberg. https://doi.org/10.1007/12_2012_170

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