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Applications of Chemical Ligation in Peptide Synthesis via Acyl Transfer

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Protein Ligation and Total Synthesis I

Part of the book series: Topics in Current Chemistry ((TOPCURRCHEM,volume 362))

Abstract

The utility of native chemical ligation (NCL) in the solution or solid phase synthesis of peptides, cyclic peptides, glycopeptides, and neoglycoconjugates is reviewed. In addition, the mechanistic details of inter- or intra-molecular NCLs are discussed from experimental and computational points of view.

✠Katritzky was deceased at the time of publication.

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Acknowledgements

We thank the University of Florida and The Kenan Foundation for financial support.

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Authors and Affiliations

  1. Department of Chemistry, Center for Heterocyclic Compounds, University of Florida, Gainesville, FL, 32611-7200, USA

    Siva S. Panda, Rachel A. Jones & C. Dennis Hall

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  1. Siva S. Panda
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  2. Rachel A. Jones
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  3. C. Dennis Hall
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  4. Alan R. Katritzky
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Correspondence to Siva S. Panda .

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  1. Department of Chemistry, Tsinghua University, Beijing, China

    Lei Liu

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Panda, S.S., Jones, R.A., Dennis Hall, C., Katritzky, A.R. (2014). Applications of Chemical Ligation in Peptide Synthesis via Acyl Transfer. In: Liu, L. (eds) Protein Ligation and Total Synthesis I. Topics in Current Chemistry, vol 362. Springer, Cham. https://doi.org/10.1007/128_2014_608

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