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Natural Products via Enzymatic Reactions pp 105–148Cite as

Chemoenzymatic and Bioenzymatic Synthesis of Carbohydrate Containing Natural Products

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Part of the book series: Topics in Current Chemistry ((TOPCURRCHEM,volume 297))

Abstract

The domain of bioactive natural products contains many oligosaccharides and aglycones decorated with various sugars. Glycan moieties influence essential aspects of biology of small molecules, such as mode of action, target recognition, pharmacokinetics, stability, and others. Methods of generation of novel glycosylated natural products are therefore of great value, as they, for example, may help fight human diseases more efficiently or provide healthier diet. This review covers the existing literature published mainly over the last decade that deals with biology-based approaches to novel glycoforms. Both genetic manipulations of biosynthesis of glycoconjugates and chemoenzymatic synthesis of novel “sweet” molecules are reviewed here. Wherever available, relationships between carbohydrate portions of the natural products and their biological activities are highlighted.

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Abbreviations

GT(s):

Glycosyltransferases

NP(s):

Natural product(s)

Ntfs:

Nucleotidylyltransferases

Susy:

Sucrose synthase

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Acknowledgments

Work in the laboratory of V. F. was generously supported by grants from Ministry of Education and Science of Ukraine and INTAS.

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Authors and Affiliations

  1. Department of Genetics and Biotechnology, Ivan Franko National University of L’viv, L’viv, 79005, Ukraine

    Bohdan Ostash & Victor Fedorenko

  2. Institut für Pharmazeutische Wissenschaften, Pharmazeutische Biologie und Biotechnologie , Albert-Ludwigs-Universität Freiburg, Freiburg, 79104, Germany

    Xiaohui Yan & Andreas Bechthold

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Correspondence to Andreas Bechthold .

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  1. Kekulé-Institut für Organische, Chemie und Biochemie, Universität Bonn, Gerhard-Domagk-Str. 1, Bonn, 53121, Germany

    Jörn Piel

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Ostash, B., Yan, X., Fedorenko, V., Bechthold, A. (2010). Chemoenzymatic and Bioenzymatic Synthesis of Carbohydrate Containing Natural Products. In: Piel, J. (eds) Natural Products via Enzymatic Reactions. Topics in Current Chemistry, vol 297. Springer, Berlin, Heidelberg. https://doi.org/10.1007/128_2010_78

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