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Engineering and Evolution of Saccharomyces cerevisiae to Produce Biofuels and Chemicals

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Synthetic Biology – Metabolic Engineering

Part of the book series: Advances in Biochemical Engineering/Biotechnology ((ABE,volume 162))

Abstract

To mitigate global climate change caused partly by the use of fossil fuels, the production of fuels and chemicals from renewable biomass has been attempted. The conversion of various sugars from renewable biomass into biofuels by engineered baker’s yeast (Saccharomyces cerevisiae) is one major direction which has grown dramatically in recent years. As well as shifting away from fossil fuels, the production of commodity chemicals by engineered S. cerevisiae has also increased significantly. The traditional approaches of biochemical and metabolic engineering to develop economic bioconversion processes in laboratory and industrial settings have been accelerated by rapid advancements in the areas of yeast genomics, synthetic biology, and systems biology. Together, these innovations have resulted in rapid and efficient manipulation of S. cerevisiae to expand fermentable substrates and diversify value-added products. Here, we discuss recent and major advances in rational (relying on prior experimentally-derived knowledge) and combinatorial (relying on high-throughput screening and genomics) approaches to engineer S. cerevisiae for producing ethanol, butanol, 2,3-butanediol, fatty acid ethyl esters, isoprenoids, organic acids, rare sugars, antioxidants, and sugar alcohols from glucose, xylose, cellobiose, galactose, acetate, alginate, mannitol, arabinose, and lactose.

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References

  1. Hubbert MK (1956) Nuclear energy and the fossil fuel. Drilling Prod Pract 36

    Google Scholar 

  2. Nigam PS, Singh A (2011) Production of liquid biofuels from renewable resources. Prog Energy Combust Sci 37:52–68

    Article  CAS  Google Scholar 

  3. Escobar JC, Lora ES, Venturini OJ, Yáñez EE, Castillo EF, Almazan O (2009) Biofuels: environment, technology and food security. Renew Sustain Energy Rev 13:1275–1287

    Article  CAS  Google Scholar 

  4. Zeng A, Biebl H (2002) Bulk chemicals from biotechnology: the case of 1,3-propanediol production and the new trends. In: Tools and applications of biochemical engineering science. Springer, Berlin, pp 239–259

    Chapter  Google Scholar 

  5. Lenihan JR, Tsuruta H, Diola D, Renninger NS, Regentin R (2008) Developing an industrial artemisinic acid fermentation process to support the cost-effective production of antimalarial artemisinin-based combination therapies. Biotechnol Prog 24:1026–1032

    Article  CAS  Google Scholar 

  6. Martinez FAC, Balciunas EM, Salgado JM, González JMD, Converti A, de Souza Oliveira RP (2013) Lactic acid properties, applications and production: a review. Trends Food Sci Technol 30:70–83

    Google Scholar 

  7. Berg P, Boland A (2014) Analysis of ultimate fossil fuel reserves and associated CO2 emissions in IPCC scenarios. Nat Resour Res 23:141–158

    Article  CAS  Google Scholar 

  8. Shafiee S, Topal E (2009) When will fossil fuel reserves be diminished? Energy Policy 37:181–189

    Article  Google Scholar 

  9. Keranen KM, Weingarten M, Abers GA, Bekins BA, Ge S (2014) Induced earthquakes. Sharp increase in central Oklahoma seismicity since 2008 induced by massive wastewater injection. Science 345:448–451

    Article  CAS  Google Scholar 

  10. Throupe R, Simons R, Mao X (2013) A review of hydro “fracking” and its potential effects on real estate. J Real Estate Lit 21:205–232

    Google Scholar 

  11. Jackson RB, Vengosh A, Carey JW, Davies RJ, Darrah TH, O’Sullivan F, Pétron G (2014) The environmental costs and benefits of fracking. Annu Rev Env Resour 39:327–362

    Article  Google Scholar 

  12. Somerville RC, Hassol SJ (2011) The science of climate change. Phys Today 64:48

    Article  Google Scholar 

  13. Hoegh-Guldberg O, Bruno JF (2010) The impact of climate change on the world’s marine ecosystems. Science 328:1523–1528

    Article  CAS  Google Scholar 

  14. Friedlingstein P, Andrew R, Rogelj J, Peters G, Canadell J, Knutti R, Luderer G, Raupach M, Schaeffer M, van Vuuren D (2014) Persistent growth of CO2 emissions and implications for reaching climate targets. Nat Geosci 7:709–715

    Article  CAS  Google Scholar 

  15. Montzka SA, Dlugokencky EJ, Butler JH (2011) Non-CO2 greenhouse gases and climate change. Nature 476:43–50

    Article  CAS  Google Scholar 

  16. Stephanopoulos G (2012) Synthetic biology and metabolic engineering. ACS Synth Biol 1:514–525

    Article  CAS  Google Scholar 

  17. Jang Y, Kim B, Shin JH, Choi YJ, Choi S, Song CW, Lee J, Park HG, Lee SY (2012) Bio-based production of C2–C6 platform chemicals. Biotechnol Bioeng 109:2437–2459

    Article  CAS  Google Scholar 

  18. Ferreira I, Pinho O, Vieira E, Tavarela J (2010) Brewer’s Saccharomyces yeast biomass: characteristics and potential applications. Trends Food Sci Technol 21:77–84

    Article  CAS  Google Scholar 

  19. Krivoruchko A, Siewers V, Nielsen J (2011) Opportunities for yeast metabolic engineering: lessons from synthetic biology. Biotechnol J 6:262–276

    Article  CAS  Google Scholar 

  20. Cherry JM, Hong EL, Amundsen C, Balakrishnan R, Binkley G, Chan ET, Christie KR, Costanzo MC, Dwight SS, Engel SR, Fisk DG, Hirschman JE, Hitz BC, Karra K, Krieger CJ, Miyasato SR, Nash RS, Park J, Skrzypek MS, Simison M, Weng S, Wong ED (2012) Saccharomyces genome database: the genomics resource of budding yeast. Nucleic Acids Res 40:D700–D705

    Article  CAS  Google Scholar 

  21. DiCarlo JE, Conley AJ, Penttilä M, Jäntti J, Wang HH, Church GM (2013) Yeast oligo-mediated genome engineering (YOGE). ACS Synth Biol 2:741–749

    Article  CAS  Google Scholar 

  22. DiCarlo JE, Norville JE, Mali P, Rios X, Aach J, Church GM (2013) Genome engineering in Saccharomyces cerevisiae using CRISPR-Cas systems. Nucleic Acids Res 41:4336–4343

    Article  CAS  Google Scholar 

  23. Abbott DA, Zelle RM, Pronk JT, Van Maris AJ (2009) Metabolic engineering of Saccharomyces cerevisiae for production of carboxylic acids: current status and challenges. FEMS Yeast Res 9:1123–1136

    Article  CAS  Google Scholar 

  24. Benjaphokee S, Hasegawa D, Yokota D, Asvarak T, Auesukaree C, Sugiyama M, Kaneko Y, Boonchird C, Harashima S (2012) Highly efficient bioethanol production by a Saccharomyces cerevisiae strain with multiple stress tolerance to high temperature, acid and ethanol. New Biotechnol 29:379–386

    Article  CAS  Google Scholar 

  25. Crook NC, Schmitz AC, Alper HS (2013) Optimization of a yeast RNA interference system for controlling gene expression and enabling rapid metabolic engineering. ACS Synth Biol 3:307–313

    Article  CAS  Google Scholar 

  26. Paddon CJ, Keasling JD (2014) Semi-synthetic artemisinin: a model for the use of synthetic biology in pharmaceutical development. Nat Rev Microbiol 12:355–367

    Article  CAS  Google Scholar 

  27. Panagiotopoulos I, Bakker R, de Vrije T, Claassen P, Koukios E (2013) Integration of first and second generation biofuels: fermentative hydrogen production from wheat grain and straw. Bioresour Technol 128:345–350

    Article  CAS  Google Scholar 

  28. Renewable Fuels Association (2014) World Fuel Ethanol Production. In: http://ethanolrfa.org/pages/World-Fuel-Ethanol-Production. Accessed 21 Sept 2015

  29. Scott F, Conejeros R, Aroca G (2013) Attainable region analysis for continuous production of second generation bioethanol. Biotechnol Biofuels 6:171-6834-6-171

    Google Scholar 

  30. Wang P, Dudareva N, Morgan JA, Chapple C (2015) Genetic manipulation of lignocellulosic biomass for bioenergy. Curr Opin Chem Biol 29:32–39

    Article  CAS  Google Scholar 

  31. Parreiras LS, Breuer RJ, Narasimhan RA, Higbee AJ, La Reau A, Tremaine M, Qin L, Willis LB, Bice BD, Bonfert BL (2014) Engineering and two-stage evolution of a lignocellulosic hydrolysate-tolerant Saccharomyces cerevisiae strain for anaerobic fermentation of xylose from AFEX pretreated corn stover. PLoS One 9:e107499

    Google Scholar 

  32. Pereira FB, Guimarães PM, Teixeira JA, Domingues L (2010) Optimization of low-cost medium for very high gravity ethanol fermentations by Saccharomyces cerevisiae using statistical experimental designs. Bioresour Technol 101:7856–7863

    Article  CAS  Google Scholar 

  33. Macrelli S, Galbe M, Wallberg O (2014) Effects of production and market factors on ethanol profitability for an integrated first and second generation ethanol plant using the whole sugarcane as feedstock. Biotechnol Biofuels 7:26–41

    Article  Google Scholar 

  34. Mullet J, Morishige D, McCormick R, Truong S, Hilley J, McKinley B, Anderson R, Olson SN, Rooney W (2014) Energy sorghum—a genetic model for the design of C4 grass bioenergy crops. J Exp Bot 65:3479–3489

    Article  Google Scholar 

  35. Behera S, Singh R, Arora R, Sharma NK, Shukla M, Kumar S (2015) Scope of algae as third generation biofuels. Front Bioeng Biotechnol 2:90

    Article  Google Scholar 

  36. Wei N, Quarterman J, Jin Y (2013) Marine macroalgae: an untapped resource for producing fuels and chemicals. Trends Biotechnol 31:70–77

    Article  CAS  Google Scholar 

  37. Carroll A, Somerville C (2009) Cellulosic biofuels. Annu Rev Plant Biol 60:165–182

    Article  CAS  Google Scholar 

  38. Kim N, Li H, Jung K, Chang HN, Lee PC (2011) Ethanol production from marine algal hydrolysates using Escherichia coli KO11. Bioresour Technol 102:7466–7469

    Article  CAS  Google Scholar 

  39. Busti S, Coccetti P, Alberghina L, Vanoni M (2010) Glucose signaling-mediated coordination of cell growth and cell cycle in Saccharomyces cerevisiae. Sensors 10:6195–6240

    Article  CAS  Google Scholar 

  40. Ding WT, Zhang GC, Liu JJ (2013) 3′ Truncation of the GPD1 promoter in Saccharomyces cerevisiae for improved ethanol yield and productivity. Appl Environ Microbiol 79:3273–3281

    Article  CAS  Google Scholar 

  41. Puligundla P, Smogrovicova D, Obulam VSR, Ko S (2011) Very high gravity (VHG) ethanolic brewing and fermentation: a research update. J Ind Microbiol Biotechnol 38:1133–1144

    Article  CAS  Google Scholar 

  42. Guadalupe-Medina V, Metz B, Oud B, Der Graaf CM, Mans R, Pronk JT, Maris AJ (2014) Evolutionary engineering of a glycerol-3-phosphate dehydrogenase-negative, acetate-reducing Saccharomyces cerevisiae strain enables anaerobic growth at high glucose concentrations. Microb Biotechnol 7:44–53

    Article  CAS  Google Scholar 

  43. Kim SR, Skerker JM, Kang W, Lesmana A, Wei N, Arkin AP, Jin Y (2013) Rational and evolutionary engineering approaches uncover a small set of genetic changes efficient for rapid xylose fermentation in Saccharomyces cerevisiae. PLoS One 8, e57048

    Article  CAS  Google Scholar 

  44. Lee SM, Jellison T, Alper HS (2014) Systematic and evolutionary engineering of a xylose isomerase-based pathway in Saccharomyces cerevisiae for efficient conversion yields. Biotechnol Biofuels 7:122-014-0122-x. eCollection 2014

    Google Scholar 

  45. Zhou H, Cheng J, Wang BL, Fink GR, Stephanopoulos G (2012) Xylose isomerase overexpression along with engineering of the pentose phosphate pathway and evolutionary engineering enable rapid xylose utilization and ethanol production by Saccharomyces cerevisiae. Metab Eng 14:611–622

    Article  CAS  Google Scholar 

  46. Sarthy AV, McConaughy BL, Lobo Z, Sundstrom JA, Furlong CE, Hall BD (1987) Expression of the Escherichia coli xylose isomerase gene in Saccharomyces cerevisiae. Appl Environ Microbiol 53:1996–2000

    CAS  Google Scholar 

  47. Kötter P, Amore R, Hollenberg CP, Ciriacy M (1990) Isolation and characterization of the Pichia stipitis xylitol dehydrogenase gene, XYL2, and construction of a xylose-utilizing Saccharomyces cerevisiae transformant. Curr Genet 18:493–500

    Article  Google Scholar 

  48. Walfridsson M, Hallborn J, Penttila M, Keranen S, Hahn-Hagerdal B (1995) Xylose-metabolizing Saccharomyces cerevisiae strains overexpressing the TKL1 and TAL1 genes encoding the pentose phosphate pathway enzymes transketolase and transaldolase. Appl Environ Microbiol 61:4184–4190

    CAS  Google Scholar 

  49. Ho NW, Chen Z, Brainard AP (1998) Genetically engineered Saccharomyces yeast capable of effective cofermentation of glucose and xylose. Appl Environ Microbiol 64:1852–1859

    CAS  Google Scholar 

  50. Chu BC, Lee H (2007) Genetic improvement of Saccharomyces cerevisiae for xylose fermentation. Biotechnol Adv 25:425–441

    Article  CAS  Google Scholar 

  51. Wisselink HW, Toirkens MJ, del Rosario Franco Berriel M, Winkler AA, van Dijken JP, Pronk JT, van Maris AJ (2007) Engineering of Saccharomyces cerevisiae for efficient anaerobic alcoholic fermentation of L-arabinose. Appl Environ Microbiol 73:4881–4891

    Article  CAS  Google Scholar 

  52. Richard P, Londesborough J, Putkonen M, Kalkkinen N, Penttila M (2001) Cloning and expression of a fungal L-arabinitol 4-dehydrogenase gene. J Biol Chem 276:40631–40637

    Article  CAS  Google Scholar 

  53. Richard P, Putkonen M, Väänänen R, Londesborough J, Penttilä M (2002) The missing link in the fungal L-arabinose catabolic pathway, identification of the L-xylulose reductase gene. Biochemistry (NY) 41:6432–6437

    Article  CAS  Google Scholar 

  54. Bettiga M, Bengtsson O, Hahn-Hagerdal B, Gorwa-Grauslund MF (2009) Arabinose and xylose fermentation by recombinant Saccharomyces cerevisiae expressing a fungal pentose utilization pathway. Microb Cell Fact 8:40-2859-8-40

    Google Scholar 

  55. Hamacher T, Becker J, Gardonyi M, Hahn-Hagerdal B, Boles E (2002) Characterization of the xylose-transporting properties of yeast hexose transporters and their influence on xylose utilization. Microbiology 148:2783–2788

    Article  CAS  Google Scholar 

  56. Becker J, Boles E (2003) A modified Saccharomyces cerevisiae strain that consumes L-arabinose and produces ethanol. Appl Environ Microbiol 69:4144–4150

    Article  CAS  Google Scholar 

  57. Leandro M, Gonçalves P, Spencer-Martins I (2006) Two glucose/xylose transporter genes from the yeast Candida intermedia: first molecular characterization of a yeast xylose-H symporter. Biochem J 395:543–549

    Article  CAS  Google Scholar 

  58. Young EM, Comer AD, Huang H, Alper HS (2012) A molecular transporter engineering approach to improving xylose catabolism in Saccharomyces cerevisiae. Metab Eng 14:401–411

    Article  CAS  Google Scholar 

  59. Wang C, Bao X, Li Y, Jiao C, Hou J, Zhang Q, Zhang W, Liu W, Shen Y (2015) Cloning and characterization of heterologous transporters in Saccharomyces cerevisiae and identification of important amino acids for xylose utilization. Metab Eng 30:79–88

    Article  CAS  Google Scholar 

  60. Young EM, Tong A, Bui H, Spofford C, Alper HS (2014) Rewiring yeast sugar transporter preference through modifying a conserved protein motif. Proc Natl Acad Sci U S A 111:131–136

    Article  CAS  Google Scholar 

  61. Subtil T, Boles E (2011) Improving L-arabinose utilization of pentose fermenting Saccharomyces cerevisiae cells by heterologous expression of L-arabinose transporting sugar transporters. Biotechnol Biofuels 4:38-6834-4-38

    Google Scholar 

  62. Wang C, Shen Y, Zhang Y, Suo F, Hou J, Bao X (2013) Improvement of L-arabinose fermentation by modifying the metabolic pathway and transport in Saccharomyces cerevisiae. BioMed Res Int 2013:1–9

    Google Scholar 

  63. Hamelinck CN, Van Hooijdonk G, Faaij AP (2005) Ethanol from lignocellulosic biomass: techno-economic performance in short-, middle- and long-term. Biomass Bioenergy 28:384–410

    Article  CAS  Google Scholar 

  64. Galazka JM, Tian C, Beeson WT, Martinez B, Glass NL, Cate JH (2010) Cellodextrin transport in yeast for improved biofuel production. Science 330:84–86

    Article  CAS  Google Scholar 

  65. Ha S, Galazka JM, Oh EJ, Kordić V, Kim H, Jin Y, Cate JH (2013) Energetic benefits and rapid cellobiose fermentation by Saccharomyces cerevisiae expressing cellobiose phosphorylase and mutant cellodextrin transporters. Metab Eng 15:134–143

    Article  CAS  Google Scholar 

  66. Ha SJ, Galazka JM, Kim SR, Choi JH, Yang X, Seo JH, Glass NL, Cate JH, Jin YS (2011) Engineered Saccharomyces cerevisiae capable of simultaneous cellobiose and xylose fermentation. Proc Natl Acad Sci U S A 108:504–509

    Article  CAS  Google Scholar 

  67. Li S, Du J, Sun J, Galazka JM, Glass NL, Cate JH, Yang X, Zhao H (2010) Overcoming glucose repression in mixed sugar fermentation by co-expressing a cellobiose transporter and a β-glucosidase in Saccharomyces cerevisiae. Mol BioSyst 6:2129–2132

    Article  CAS  Google Scholar 

  68. Ha SJ, Wei Q, Kim SR, Galazka JM, Cate JH, Jin YS (2011) Cofermentation of cellobiose and galactose by an engineered Saccharomyces cerevisiae strain. Appl Environ Microbiol 77:5822–5825

    Article  CAS  Google Scholar 

  69. Pawar SN, Edgar KJ (2012) Alginate derivatization: a review of chemistry, properties and applications. Biomaterials 33:3279–3305

    Article  CAS  Google Scholar 

  70. Wargacki AJ, Leonard E, Win MN, Regitsky DD, Santos CN, Kim PB, Cooper SR, Raisner RM, Herman A, Sivitz AB, Lakshmanaswamy A, Kashiyama Y, Baker D, Yoshikuni Y (2012) An engineered microbial platform for direct biofuel production from brown macroalgae. Science 335:308–313

    Article  CAS  Google Scholar 

  71. Enquist-Newman M, Faust AME, Bravo DD, Santos CNS, Raisner RM, Hanel A, Sarvabhowman P, Le C, Regitsky DD, Cooper SR (2014) Efficient ethanol production from brown macroalgae sugars by a synthetic yeast platform. Nature 505:239–243

    Article  CAS  Google Scholar 

  72. Lee K, Hong M, Jung S, Ha S, Yu BJ, Koo HM, Park SM, Seo J, Kweon D, Park JC (2011) Improved galactose fermentation of Saccharomyces cerevisiae through inverse metabolic engineering. Biotechnol Bioeng 108:621–631

    Article  CAS  Google Scholar 

  73. Ra CH, Kim YJ, Lee SY, Jeong G, Kim S (2015) Effects of galactose adaptation in yeast for ethanol fermentation from red seaweed, Gracilaria verrucosa. Bioprocess Biosyst Eng :1–8

    Google Scholar 

  74. Kim H, Ra CH, Kim S (2013) Ethanol production from seaweed (Undaria pinnatifida) using yeast acclimated to specific sugars. Biotechnol Bioprocess Eng 18:533–537

    Article  CAS  Google Scholar 

  75. Patwardhan PR, Brown RC, Shanks BH (2011) Understanding the fast pyrolysis of lignin. ChemSusChem 4:1629–1636

    Article  CAS  Google Scholar 

  76. Wang K, Kim KH, Brown RC (2014) Catalytic pyrolysis of individual components of lignocellulosic biomass. Green Chem 16:727–735

    Article  CAS  Google Scholar 

  77. Wei N, Quarterman J, Kim SR, Cate JH, Jin Y (2013) Enhanced biofuel production through coupled acetic acid and xylose consumption by engineered yeast. Nat Commun 4:2580

    Google Scholar 

  78. Wei N, Oh EJ, Million G, Cate JH, Jin Y (2015) Simultaneous utilization of cellobiose, xylose, and acetic acid from lignocellulosic biomass for biofuel production by an engineered yeast platform. ACS Synth Biol 4:707–713

    Article  CAS  Google Scholar 

  79. Zhang G, Kong II, Wei N, Peng D, Turner TL, Sung BH, Sohn J, Jin Y (2016) Optimization of an acetate reduction pathway for producing cellulosic ethanol by engineered yeast. Biotechnol Bioeng 113:2587–2596

    Article  CAS  Google Scholar 

  80. Domingues L, Lima N, Teixeira JA (2001) Alcohol production from cheese whey permeate using genetically modified flocculent yeast cells. Biotechnol Bioeng 72:507–514

    Google Scholar 

  81. Guimaraes PM, Francois J, Parrou JL, Teixeira JA, Domingues L (2008) Adaptive evolution of a lactose-consuming Saccharomyces cerevisiae recombinant. Appl Environ Microbiol 74:1748–1756

    Article  CAS  Google Scholar 

  82. Guimarães PM, Teixeira JA, Domingues L (2008) Fermentation of high concentrations of lactose to ethanol by engineered flocculent Saccharomyces cerevisiae. Biotechnol Lett 30:1953–1958

    Article  CAS  Google Scholar 

  83. Sreekrishna K, Dickson RC (1985) Construction of strains of Saccharomyces cerevisiae that grow on lactose. Proc Natl Acad Sci U S A 82:7909–7913

    Article  CAS  Google Scholar 

  84. Zou J, Guo X, Shen T, Dong J, Zhang C, Xiao D (2013) Construction of lactose-consuming Saccharomyces cerevisiae for lactose fermentation into ethanol fuel. J Ind Microbiol Biotechnol 40:353–363

    Article  CAS  Google Scholar 

  85. Doyon Y, Vo TD, Mendel MC, Greenberg SG, Wang J, Xia DF, Miller JC, Urnov FD, Gregory PD, Holmes MC (2011) Enhancing zinc-finger-nuclease activity with improved obligate heterodimeric architectures. Nat Methods 8:74–79

    Article  CAS  Google Scholar 

  86. Mosier NS, Ileleji KE (2014) How fuel ethanol is made from corn. Bioenerg Biomass Biofuel 379–384

    Google Scholar 

  87. Ansell R, Granath K, Hohmann S, Thevelein JM, Adler L (1997) The two isoenzymes for yeast NAD+-dependent glycerol 3-phosphate dehydrogenase encoded by GPD1 and GPD2 have distinct roles in osmoadaptation and redox regulation. EMBO J 16:2179–2187

    Article  CAS  Google Scholar 

  88. Valadi H, Larsson C, Gustafsson L (1998) Improved ethanol production by glycerol-3-phosphate dehydrogenase mutants of Saccharomyces cerevisiae. Appl Microbiol Biotechnol 50:434–439

    Article  CAS  Google Scholar 

  89. Hohmann S (2002) Osmotic stress signaling and osmoadaptation in yeasts. Microbiol Mol Biol Rev 66:300–372

    Article  CAS  Google Scholar 

  90. Nissen TL, Kielland-Brandt MC, Nielsen J, Villadsen J (2000) Optimization of ethanol production in Saccharomyces cerevisiae by metabolic engineering of the ammonium assimilation. Metab Eng 2:69–77

    Article  CAS  Google Scholar 

  91. Bro C, Regenberg B, Förster J, Nielsen J (2006) In silico aided metabolic engineering of Saccharomyces cerevisiae for improved bioethanol production. Metab Eng 8:102–111

    Article  CAS  Google Scholar 

  92. Guo Z, Zhang L, Ding Z, Shi G (2011) Minimization of glycerol synthesis in industrial ethanol yeast without influencing its fermentation performance. Metab Eng 13:49–59

    Article  CAS  Google Scholar 

  93. Guadalupe Medina V, Almering MJ, van Maris AJ, Pronk JT (2010) Elimination of glycerol production in anaerobic cultures of a Saccharomyces cerevisiae strain engineered to use acetic acid as an electron acceptor. Appl Environ Microbiol 76:190–195

    Article  CAS  Google Scholar 

  94. Zhang L, Tang Y, Guo Z, Ding Z, Shi G (2011) Improving the ethanol yield by reducing glycerol formation using cofactor regulation in Saccharomyces cerevisiae. Biotechnol Lett 33:1375–1380

    Article  CAS  Google Scholar 

  95. Zhang A, Kong Q, Cao L, Chen X (2007) Effect of FPS1 deletion on the fermentation properties of Saccharomyces cerevisiae. Lett Appl Microbiol 44:212–217

    Article  CAS  Google Scholar 

  96. Hubmann G, Guillouet S, Nevoigt E (2011) Gpd1 and Gpd2 fine-tuning for sustainable reduction of glycerol formation in Saccharomyces cerevisiae. Appl Environ Microbiol 77:5857–5867

    Article  CAS  Google Scholar 

  97. Shen CR, Lan EI, Dekishima Y, Baez A, Cho KM, Liao JC (2011) Driving forces enable high-titer anaerobic 1-butanol synthesis in Escherichia coli. Appl Environ Microbiol 77:2905–2915

    Article  CAS  Google Scholar 

  98. Steen EJ, Chan R, Prasad N, Myers S, Petzold CJ, Redding A, Ouellet M, Keasling JD (2008) Metabolic engineering of Saccharomyces cerevisiae for the production of n-butanol. Microb Cell Fact 7:36

    Article  CAS  Google Scholar 

  99. Krivoruchko A, Serrano-Amatriain C, Chen Y, Siewers V, Nielsen J (2013) Improving biobutanol production in engineered Saccharomyces cerevisiae by manipulation of acetyl-CoA metabolism. J Ind Microbiol Biotechnol 40:1051–1056

    Article  CAS  Google Scholar 

  100. Lian J, Si T, Nair NU, Zhao H (2014) Design and construction of acetyl-CoA overproducing Saccharomyces cerevisiae strains. Metab Eng 24:139–149

    Article  CAS  Google Scholar 

  101. Si T, Luo Y, Xiao H, Zhao H (2014) Utilizing an endogenous pathway for 1-butanol production in Saccharomyces cerevisiae. Metab Eng 22:60–68

    Article  CAS  Google Scholar 

  102. Chen X, Nielsen KF, Borodina I, Kielland-Brandt MC, Karhumaa K (2011) Increased isobutanol production in Saccharomyces cerevisiae by overexpression of genes in valine metabolism. Biotechnol Biofuels 4:2089–2090

    Article  CAS  Google Scholar 

  103. Avalos JL, Fink GR, Stephanopoulos G (2013) Compartmentalization of metabolic pathways in yeast mitochondria improves the production of branched-chain alcohols. Nat Biotechnol 31:335–341

    Article  CAS  Google Scholar 

  104. Yuan J, Ching CB (2014) Combinatorial assembly of large biochemical pathways into yeast chromosomes for improved production of value-added compounds. ACS Synth Biol 4:23–31

    Article  CAS  Google Scholar 

  105. Brat D, Weber C, Lorenzen W, Bode HB, Boles E (2012) Cytosolic re-localization and optimization of valine synthesis and catabolism enables increased isobutanol production with the yeast Saccharomyces cerevisiae. Biotechnol Biofuels 5:65

    Article  CAS  Google Scholar 

  106. Matsuda F, Ishii J, Kondo T, Ida K, Tezuka H, Kondo A (2013) Increased isobutanol production in Saccharomyces cerevisiae by eliminating competing pathways and resolving cofactor imbalance. Microb Cell Fact 12:119

    Article  CAS  Google Scholar 

  107. Huo Y, Cho KM, Rivera JGL, Monte E, Shen CR, Yan Y, Liao JC (2011) Conversion of proteins into biofuels by engineering nitrogen flux. Nat Biotechnol 29:346–351

    Article  CAS  Google Scholar 

  108. Kalscheuer R, Luftmann H, Steinbuchel A (2004) Synthesis of novel lipids in Saccharomyces cerevisiae by heterologous expression of an unspecific bacterial acyltransferase. Appl Environ Microbiol 70:7119–7125

    Article  CAS  Google Scholar 

  109. Shi S, Valle-Rodríguez JO, Khoomrung S, Siewers V, Nielsen J (2012) Functional expression and characterization of five wax ester synthases in Saccharomyces cerevisiae and their utility for biodiesel production. Biotechnol Biofuels 5:10.1186

    Article  Google Scholar 

  110. de Jong BW, Shi S, Siewers V, Nielsen J (2014) Improved production of fatty acid ethyl esters in Saccharomyces cerevisiae through up-regulation of the ethanol degradation pathway and expression of the heterologous phosphoketolase pathway. Microb Cell Fact 13:39

    Article  CAS  Google Scholar 

  111. Valle-Rodríguez JO, Shi S, Siewers V, Nielsen J (2014) Metabolic engineering of Saccharomyces cerevisiae for production of fatty acid ethyl esters, an advanced biofuel, by eliminating non-essential fatty acid utilization pathways. Appl Energy 115:226–232

    Article  CAS  Google Scholar 

  112. Eriksen DT, HamediRad M, Yuan Y, Zhao H (2015) Orthogonal fatty acid biosynthetic pathway improves fatty acid ethyl ester production in Saccharomyces cerevisiae. ACS Synth Biol 4:808–814

    Article  CAS  Google Scholar 

  113. Costenoble R, Picotti P, Reiter L, Stallmach R, Heinemann M, Sauer U, Aebersold R (2011) Comprehensive quantitative analysis of central carbon and amino-acid metabolism in Saccharomyces cerevisiae under multiple conditions by targeted proteomics. Mol Syst Biol 7:464

    Article  CAS  Google Scholar 

  114. Galanie S, Thodey K, Trenchard IJ, Filsinger Interrante M, Smolke CD (2015) Complete biosynthesis of opioids in yeast. Science 349:1095–1100

    Article  CAS  Google Scholar 

  115. Ng CY, Jung M, Lee J, Oh M (2012) Production of 2,3-butanediol in Saccharomyces cerevisiae by in silico aided metabolic engineering. Microb Cell Fact 11:68

    Article  CAS  Google Scholar 

  116. Kim S, Seo S, Jin Y, Seo J (2013) Production of 2,3-butanediol by engineered Saccharomyces cerevisiae. Bioresour Technol 146:274–281

    Article  CAS  Google Scholar 

  117. Kim J, Seo S, Zhang G, Jin Y, Seo J (2015) Expression of Lactococcus lactis NADH oxidase increases 2,3-butanediol production in Pdc-deficient Saccharomyces cerevisiae. Bioresour Technol 191:512–519

    Article  CAS  Google Scholar 

  118. Kim S, Hahn J (2015) Efficient production of 2,3-butanediol in Saccharomyces cerevisiae by eliminating ethanol and glycerol production and redox rebalancing. Metab Eng 31:94–101

    Article  CAS  Google Scholar 

  119. George KW, Alonso-Gutierrez J, Keasling JD, Lee TS (2015) Isoprenoid drugs, biofuels, and chemicals—artemisinin, farnesene, and beyond. In: Biotechnology of isoprenoids. Springer, Cham, pp 355–389

    Chapter  Google Scholar 

  120. Tippmann S, Chen Y, Siewers V, Nielsen J (2013) From flavors and pharmaceuticals to advanced biofuels: production of isoprenoids in Saccharomyces cerevisiae. Biotechnol J 8:1435–1444

    Article  CAS  Google Scholar 

  121. Brennan TC, Turner CD, Krömer JO, Nielsen LK (2012) Alleviating monoterpene toxicity using a two‐phase extractive fermentation for the bioproduction of jet fuel mixtures in Saccharomyces cerevisiae. Biotechnol Bioeng 109:2513–2522

    Article  CAS  Google Scholar 

  122. Fischer MJ, Meyer S, Claudel P, Bergdoll M, Karst F (2011) Metabolic engineering of monoterpene synthesis in yeast. Biotechnol Bioeng 108:1883–1892

    Article  CAS  Google Scholar 

  123. Albertsen L, Chen Y, Bach LS, Rattleff S, Maury J, Brix S, Nielsen J, Mortensen UH (2011) Diversion of flux toward sesquiterpene production in Saccharomyces cerevisiae by fusion of host and heterologous enzymes. Appl Environ Microbiol 77:1033–1040

    Article  CAS  Google Scholar 

  124. d’Espaux L, Mendez-Perez D, Li R, Keasling JD (2015) Synthetic biology for microbial production of lipid-based biofuels. Curr Opin Chem Biol 29:58–65

    Article  CAS  Google Scholar 

  125. Ignea C, Cvetkovic I, Loupassaki S, Kefalas P, Johnson CB, Kampranis SC, Makris AM (2011) Improving yeast strains using recyclable integration cassettes, for the production of plant terpenoids. Microb Cell Fact 10:1–18

    Article  CAS  Google Scholar 

  126. Peralta-Yahya PP, Ouellet M, Chan R, Mukhopadhyay A, Keasling JD, Lee TS (2011) Identification and microbial production of a terpene-based advanced biofuel. Nat Commun 2:483

    Article  CAS  Google Scholar 

  127. Özaydın B, Burd H, Lee TS, Keasling JD (2013) Carotenoid-based phenotypic screen of the yeast deletion collection reveals new genes with roles in isoprenoid production. Metab Eng 15:174–183

    Article  CAS  Google Scholar 

  128. Engels B, Dahm P, Jennewein S (2008) Metabolic engineering of taxadiene biosynthesis in yeast as a first step towards Taxol (Paclitaxel) production. Metab Eng 10:201–206

    Article  CAS  Google Scholar 

  129. Zhou YJ, Gao W, Rong Q, Jin G, Chu H, Liu W, Yang W, Zhu Z, Li G, Zhu G (2012) Modular pathway engineering of diterpenoid synthases and the mevalonic acid pathway for miltiradiene production. J Am Chem Soc 134:3234–3241

    Article  CAS  Google Scholar 

  130. Dai Z, Liu Y, Huang L, Zhang X (2012) Production of miltiradiene by metabolically engineered Saccharomyces cerevisiae. Biotechnol Bioeng 109:2845–2853

    Article  CAS  Google Scholar 

  131. White NJ (1997) Assessment of the pharmacodynamic properties of antimalarial drugs in vivo. Antimicrob Agents Chemother 41:1413–1422

    CAS  Google Scholar 

  132. Tu Y (2011) The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine. Nat Med 17:1217–1220

    Article  CAS  Google Scholar 

  133. Kindermans J, Pilloy J, Olliaro P, Gomes M (2007) Ensuring sustained ACT production and reliable artemisinin supply. Malar J 6:125

    Google Scholar 

  134. Lindahl A, Olsson ME, Mercke P, Tollbom Ö, Schelin J, Brodelius M, Brodelius PE (2006) Production of the artemisinin precursor amorpha-4,11-diene by engineered Saccharomyces cerevisiae. Biotechnol Lett 28:571–580

    Article  CAS  Google Scholar 

  135. Ro D, Paradise EM, Ouellet M, Fisher KJ, Newman KL, Ndungu JM, Ho KA, Eachus RA, Ham TS, Kirby J (2006) Production of the antimalarial drug precursor artemisinic acid in engineered yeast. Nature 440:940–943

    Article  CAS  Google Scholar 

  136. Westfall PJ, Pitera DJ, Lenihan JR, Eng D, Woolard FX, Regentin R, Horning T, Tsuruta H, Melis DJ, Owens A, Fickes S, Diola D, Benjamin KR, Keasling JD, Leavell MD, McPhee DJ, Renninger NS, Newman JD, Paddon CJ (2012) Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin. Proc Natl Acad Sci U S A 109:E111–E118

    Article  CAS  Google Scholar 

  137. Auras RA, Lim L, Selke SE, Tsuji H (2011) Poly(lactic acid): synthesis, structures, properties, processing, and applications. Wiley

    Google Scholar 

  138. John RP, Nampoothiri KM, Pandey A (2007) Fermentative production of lactic acid from biomass: an overview on process developments and future perspectives. Appl Microbiol Biotechnol 74:524–534

    Article  CAS  Google Scholar 

  139. Ishida N, Saitoh S, Onishi T, Tokuhiro K, Nagamori E, Kitamoto K, Takahashi H (2006) The effect of pyruvate decarboxylase gene knockout in Saccharomyces cerevisiae on L-lactic acid production. Biosci Biotechnol Biochem 70:1148–1153

    Article  CAS  Google Scholar 

  140. Turner TL, Zhang G, Kim SR, Subramaniam V, Steffen D, Skory CD, Jang JY, Yu BJ, Jin Y (2015) Lactic acid production from xylose by engineered Saccharomyces cerevisiae without PDC or ADH deletion. Appl Microbiol Biotechnol 99(19):8023–8033

    Article  CAS  Google Scholar 

  141. Turner TL, Zhang G, Oh EJ, Subramaniam V, Adiputra A, Subramaniam V, Skory CD, Jang JY, Yu BJ, Park I (2015) Lactic acid production from cellobiose and xylose by engineered Saccharomyces cerevisiae. Biotechnol Bioeng 113:1075–1083

    Article  CAS  Google Scholar 

  142. Ishida N, Saitoh S, Tokuhiro K, Nagamori E, Matsuyama T, Kitamoto K, Takahashi H (2005) Efficient production of L-lactic acid by metabolically engineered Saccharomyces cerevisiae with a genome-integrated L-lactate dehydrogenase gene. Appl Environ Microbiol 71:1964–1970

    Article  CAS  Google Scholar 

  143. Saitoh S, Ishida N, Onishi T, Tokuhiro K, Nagamori E, Kitamoto K, Takahashi H (2005) Genetically engineered wine yeast produces a high concentration of L-lactic acid of extremely high optical purity. Appl Environ Microbiol 71:2789–2792

    Article  CAS  Google Scholar 

  144. Skory CD (2003) Lactic acid production by Saccharomyces cerevisiae expressing a Rhizopus oryzae lactate dehydrogenase gene. J Ind Microbiol Biotechnol 30:22–27

    Article  CAS  Google Scholar 

  145. Colombié S, Dequin S, Sablayrolles JM (2003) Control of lactate production by Saccharomyces cerevisiae expressing a bacterial LDH gene. Enzyme Microb Technol 33:38–46

    Article  CAS  Google Scholar 

  146. Colombié S, Sablayrolles J (2004) Nicotinic acid controls lactate production by K1-LDH: a Saccharomyces cerevisiae strain expressing a bacterial LDH gene. J Ind Microbiol Biotechnol 31:209–215

    Article  CAS  Google Scholar 

  147. Tate BE (1967) Polymerization of itaconic acid and derivatives. In: Fortschritte der Hochpolymeren-Forschung. Springer, Berlin, pp 214–232

    Chapter  Google Scholar 

  148. Blazeck J, Miller J, Pan A, Gengler J, Holden C, Jamoussi M, Alper HS (2014) Metabolic engineering of Saccharomyces cerevisiae for itaconic acid production. Appl Microbiol Biotechnol 98:8155–8164

    Article  CAS  Google Scholar 

  149. Xie N, Liang H, Huang R, Xu P (2014) Biotechnological production of muconic acid: current status and future prospects. Biotechnol Adv 32:615–622

    Article  CAS  Google Scholar 

  150. Weber C, Bruckner C, Weinreb S, Lehr C, Essl C, Boles E (2012) Biosynthesis of cis,cis-muconic acid and its aromatic precursors, catechol and protocatechuic acid, from renewable feedstocks by Saccharomyces cerevisiae. Appl Environ Microbiol 78:8421–8430

    Article  CAS  Google Scholar 

  151. Curran KA, Leavitt JM, Karim AS, Alper HS (2013) Metabolic engineering of muconic acid production in Saccharomyces cerevisiae. Metab Eng 15:55–66

    Article  CAS  Google Scholar 

  152. Yan D, Wang C, Zhou J, Liu Y, Yang M, Xing J (2014) Construction of reductive pathway in Saccharomyces cerevisiae for effective succinic acid fermentation at low pH value. Bioresour Technol 156:232–239

    Article  CAS  Google Scholar 

  153. Agren R, Otero JM, Nielsen J (2013) Genome-scale modeling enables metabolic engineering of Saccharomyces cerevisiae for succinic acid production. J Ind Microbiol Biotechnol 40:735–747

    Article  CAS  Google Scholar 

  154. Otero JM, Cimini D, Patil KR, Poulsen SG, Olsson L, Nielsen J (2013) Industrial systems biology of Saccharomyces cerevisiae enables novel succinic acid cell factory. PLoS One 8, e54144

    Article  CAS  Google Scholar 

  155. Goerz O, Ritter H (2013) Polymers with shape memory effect from renewable resources: crosslinking of polyesters based on isosorbide, itaconic acid and succinic acid. Polym Int 62:709–712

    Article  CAS  Google Scholar 

  156. Koivistoinen OM, Kuivanen J, Barth D, Turkia H, Pitkänen J, Penttilä M, Richard P (2013) Glycolic acid production in the engineered yeasts Saccharomyces cerevisiae and Kluyveromyces lactis. Microb Cell Fact 12:1

    Article  CAS  Google Scholar 

  157. Beerens K, Desmet T, Soetaert W (2012) Enzymes for the biocatalytic production of rare sugars. J Ind Microbiol Biotechnol 39:823–834

    Article  CAS  Google Scholar 

  158. Hu C, Li L, Zheng Y, Rui L, Hu C (2011) Perspectives of biotechnological production of L-ribose and its purification. Appl Microbiol Biotechnol 92:449–455

    Article  CAS  Google Scholar 

  159. Okano K (2009) Synthesis and pharmaceutical application of L-ribose. Tetrahedron 65:1937–1949

    Article  CAS  Google Scholar 

  160. Milgrom P, Ly KA (2012) The role of sugar alcohols, xylitol, and chewing gum in preventing dental diseases. Comprehensive preventive dentistry. Wiley, West Sussex, pp 146–158

    Google Scholar 

  161. Ingram JM, Wood WA (1965) Enzymatic basis for D-arbitol production by Saccharomyces rouxii. J Bacteriol 89:1186–1194

    CAS  Google Scholar 

  162. Chaturvedi V, Bartiss A, Wong B (1997) Expression of bacterial mtlD in Saccharomyces cerevisiae results in mannitol synthesis and protects a glycerol-defective mutant from high-salt and oxidative stress. J Bacteriol 179:157–162

    Article  CAS  Google Scholar 

  163. Costenoble R, Adler L, Niklasson C, Liden G (2003) Engineering of the metabolism of Saccharomyces cerevisiae for anaerobic production of mannitol. FEMS Yeast Res 3:17–25

    CAS  Google Scholar 

  164. Wisniak J, Hershkowitz M, Leibowitz R, Stein S (1974) Hydrogenation of xylose to xylitol. Ind Eng Chem Prod Res Dev 13:75–79

    Article  CAS  Google Scholar 

  165. Oh E, Bae Y, Kim K, Park Y, Seo J (2012) Effects of overexpression of acetaldehyde dehydrogenase 6 and acetyl-CoA synthetase 1 on xylitol production in recombinant Saccharomyces cerevisiae. Biocatal Agric Biotechnol 1:15–19

    CAS  Google Scholar 

  166. Oh EJ, Ha S, Rin Kim S, Lee W, Galazka JM, Cate JH, Jin Y (2013) Enhanced xylitol production through simultaneous co-utilization of cellobiose and xylose by engineered Saccharomyces cerevisiae. Metab Eng 15:226–234

    Article  CAS  Google Scholar 

  167. Jo J, Oh S, Lee H, Park Y, Seo J (2015) Dual utilization of NADPH and NADH cofactors enhances xylitol production in engineered Saccharomyces cerevisiae. Biotechnol J 10:1935–1943

    Article  CAS  Google Scholar 

  168. Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, Prabhu VV, Allard JS, Lopez-Lluch G, Lewis K (2006) Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444:337–342

    Article  CAS  Google Scholar 

  169. Becker JV, Armstrong GO, van der Merwe MJ, Lambrechts MG, Vivier MA, Pretorius IS (2003) Metabolic engineering of Saccharomyces cerevisiae for the synthesis of the wine-related antioxidant resveratrol. FEMS Yeast Res 4:79–85

    Article  CAS  Google Scholar 

  170. Beekwilder J, Wolswinkel R, Jonker H, Hall R, de Vos CH, Bovy A (2006) Production of resveratrol in recombinant microorganisms. Appl Environ Microbiol 72:5670–5672

    Article  CAS  Google Scholar 

  171. Sydor T, Schaffer S, Boles E (2010) Considerable increase in resveratrol production by recombinant industrial yeast strains with use of rich medium. Appl Environ Microbiol 76:3361–3363

    Article  CAS  Google Scholar 

  172. Wang Y, Halls C, Zhang J, Matsuno M, Zhang Y, Yu O (2011) Stepwise increase of resveratrol biosynthesis in yeast Saccharomyces cerevisiae by metabolic engineering. Metab Eng 13:455–463

    Article  CAS  Google Scholar 

  173. Hara KY, Kiriyama K, Inagaki A, Nakayama H, Kondo A (2012) Improvement of glutathione production by metabolic engineering the sulfate assimilation pathway of Saccharomyces cerevisiae. Appl Microbiol Biotechnol 94:1313–1319

    Article  CAS  Google Scholar 

  174. Taskin M (2013) A new strategy for improved glutathione production from Saccharomyces cerevisiae: use of cysteine‐and glycine‐rich chicken feather protein hydrolysate as a new cheap substrate. J Sci Food Agric 93:535–541

    Article  CAS  Google Scholar 

  175. Zhao Y, Bian X, You X, Shao F, Xiang X, Deng X, Zhao G, Xu J (2013) Nystatin‐enhanced glutathione production by Saccharomyces cerevisiae depends on γ‐glutamylcysteine synthase activity and K. Eng Life Sci 13:156–162

    Article  CAS  Google Scholar 

  176. Mezzetti F, De Vero L, Giudici P (2014) Evolved Saccharomyces cerevisiae wine strains with enhanced glutathione production obtained by an evolution-based strategy. FEMS Yeast Res 14:977–987

    Article  CAS  Google Scholar 

  177. Oraby MM, Allababidy M, Ramadan E (2014) Enhancement of antioxidant glutathione production by Saccharomyces cerevisiae growing under stressful condition. Int J 5:160–165

    Google Scholar 

  178. Patzschke A, Steiger MG, Holz C, Lang C, Mattanovich D, Sauer M (2015) Enhanced glutathione production by evolutionary engineering of Saccharomyces cerevisiae strains. Biotechnol J 10:1719–1726

    Article  CAS  Google Scholar 

  179. Li Y, Wei G, Chen J (2004) Glutathione: a review on biotechnological production. Appl Microbiol Biotechnol 66:233–242

    Article  CAS  Google Scholar 

  180. Kwolek-Mirek M, Bednarska S, Bartosz G, Biliński T (2009) Acrolein toxicity involves oxidative stress caused by glutathione depletion in the yeast Saccharomyces cerevisiae. Cell Biol Toxicol 25:363–378

    Article  CAS  Google Scholar 

  181. Vollenweider S, Evers S, Zurbriggen K, Lacroix C (2010) Unraveling the hydroxypropionaldehyde (HPA) system: an active antimicrobial agent against human pathogens. J Agric Food Chem 58:10315–10322

    Article  CAS  Google Scholar 

  182. Bakhiet SE, Mahmoud MA (2015) Production of bio-ethanol from molasses by Schizosaccharomyces species. Annu Res Rev Biol 7:45–53

    Article  Google Scholar 

  183. Tai M, Stephanopoulos G (2013) Engineering the push and pull of lipid biosynthesis in oleaginous yeast Yarrowia lipolytica for biofuel production. Metab Eng 15:1–9

    Article  CAS  Google Scholar 

  184. Goeddel DV, Kleid DG, Bolivar F, Heyneker HL, Yansura DG, Crea R, Hirose T, Kraszewski A, Itakura K, Riggs AD (1979) Expression in Escherichia coli of chemically synthesized genes for human insulin. Proc Natl Acad Sci U S A 76:106–110

    Article  CAS  Google Scholar 

  185. Huang C, Lin H, Yang X (2012) Industrial production of recombinant therapeutics in Escherichia coli and its recent advancements. J Ind Microbiol Biotechnol 39:383–399

    Article  CAS  Google Scholar 

  186. Geddes CC, Nieves IU, Ingram LO (2011) Advances in ethanol production. Curr Opin Biotechnol 22:312–319

    Article  CAS  Google Scholar 

  187. Jang Y, Park JM, Choi S, Choi YJ, Cho JH, Lee SY (2012) Engineering of microorganisms for the production of biofuels and perspectives based on systems metabolic engineering approaches. Biotechnol Adv 30:989–1000

    Article  CAS  Google Scholar 

  188. Anderson J, DiCicco D, Ginder J, Kramer U, Leone T, Raney-Pablo H, Wallington T (2012) High octane number ethanol–gasoline blends: quantifying the potential benefits in the United States. Fuel 97:585–594

    Article  CAS  Google Scholar 

  189. United States Environmental Protection Agency (2015) EPA Proposes Renewable Fuel Standards for 2014, 2015, and 2016, and the Biomass-Based Diesel Volume for 2017. In: http://www3.epa.gov/otaq/fuels/renewablefuels/documents/420f15028.pdf. Accessed 21 Sept 2015

  190. Sissine F (2007) Energy independence and security cct of 2007: a summary of major provisions. Library of Congress, Congressional Research Service, Washington DC

    Google Scholar 

  191. de Souza Dias MO, Maciel Filho R, Mantelatto PE, Cavalett O, Rossell CEV, Bonomi A, Leal MRLV (2015) Sugarcane processing for ethanol and sugar in Brazil. Environ Dev 15:35–51

    Google Scholar 

  192. Mumm RH, Goldsmith PD, Rausch KD, Stein HH (2014) Land usage attributed to corn ethanol production in the United States: sensitivity to technological advances in corn grain yield, ethanol conversion, and co-product utilization. Biotechnol Biofuels 7:61-6834-7-61. eCollection 2014

    Google Scholar 

  193. Goldemberg J (2013) Sugarcane ethanol: strategies to a successful program in Brazil. In: Advanced biofuels and bioproducts. Springer, New York, pp 13–20

    Chapter  Google Scholar 

  194. Wallington T, Anderson J, Mueller S, Kolinski Morris E, Winkler S, Ginder J, Nielsen OJ (2012) Corn ethanol production, food exports, and indirect land use change. Environ Sci Technol 46:6379–6384

    Article  CAS  Google Scholar 

  195. IPCC (2014) Climate Change 2014: impacts, adaptation, and vulnerability. Part A: global and sectoral aspects. In: Field CB, Barros VR, Dokken DJ, Mach KJ, Mastrandrea MD, Bilir TE, Chatterjee M, Ebi KL, Estrada YO, Genova RC, Girma B, Kissel ES, Levy AN, MacCracken S, Mastrandrea PR, White LL (eds) Contribution of working group II to the fifth assessment report of the intergovernmental panel on climate change. Cambridge University Press, Canbridge/New York, p 1132

    Google Scholar 

  196. Kircher M (2012) The transition to a bio‐economy: emerging from the oil age. Biofuels Bioprod Biorefin 6:369–375

    Article  CAS  Google Scholar 

  197. Dale BE, Anderson JE, Brown RC, Csonka S, Dale VH, Herwick G, Jackson RD, Jordan N, Kaffka S, Kline KL (2014) Take a closer look: biofuels can support environmental, economic and social goals. Environ Sci Technol 48:7200–7203

    Article  CAS  Google Scholar 

  198. Wang Q, Li R (2016) Impact of cheaper oil on economic system and climate change: a SWOT analysis. Renew Sustain Energy Rev 54:925–931

    Article  Google Scholar 

  199. Reboredo FH, Lidon F, Pessoa F, Ramalho JC (2016) The fall of oil prices and the effects on biofuels. Trends Biotechnol 34:3–6

    Article  CAS  Google Scholar 

  200. Verwaal R, Wu L, Damveld RA, Sagt CMJ (2009) Succinic acid production in a eukaryotic cell. BMC Biotechnol 9:48

    Google Scholar 

  201. Picataggio S, Beardslee T (2013) Biological methods for preparing adipic acid. US Patent No. 8,343,752

    Google Scholar 

  202. Fruchey OS, Manzer LE, Dunuwila D, Keen BT, Albin BA, Clinton NA, Dombek BD (2011) Processes for producing butanediol (BDO), diaminobutane (DAB), succinic dinitrile (SDN) and succinamide (DAM). US Patent Application No. 14/117,141

    Google Scholar 

  203. Gardner TS, Hawkins KM, Meadows AL, Tsong AE, Tsegaye Y (2013) Production of acetyl-coenzyme a derived isoprenoids. US Patent No. 8,603,800

    Google Scholar 

  204. Miller M, Suominen P, Aristidou A, Hause BM, Van Hoek P, Dundon CA (2012) Lactic acid-producing yeast cells having nonfunctional L- or D-lactate:ferricytochrome C oxidoreductase cells. US Patent No. 8,137,953

    Google Scholar 

  205. Pinazo JM, Domine ME, Parvulescu V, Petru F (2015) Sustainability metrics for succinic acid production: a comparison between biomass-based and petrochemical routes. Catal Today 239:17–24

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA

    Timothy L. Turner, Heejin Kim, In Iok Kong, Jing-Jing Liu, Guo-Chang Zhang & Yong-Su Jin

  2. Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA

    Heejin Kim, In Iok Kong, Jing-Jing Liu & Yong-Su Jin

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  1. Timothy L. Turner
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Correspondence to Yong-Su Jin .

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  1. Department of Chemical and Biomolecular Engineering, University of Illinois, Urbana, Illinois, USA

    Huimin Zhao

  2. Institut für Bioprozess- und Biosystemtechnik, Technische Universitðt Hamburg-Harburg, Hamburg, Germany

    An-Ping Zeng

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Turner, T.L., Kim, H., Kong, I.I., Liu, JJ., Zhang, GC., Jin, YS. (2016). Engineering and Evolution of Saccharomyces cerevisiae to Produce Biofuels and Chemicals. In: Zhao, H., Zeng, AP. (eds) Synthetic Biology – Metabolic Engineering. Advances in Biochemical Engineering/Biotechnology, vol 162. Springer, Cham. https://doi.org/10.1007/10_2016_22

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