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Apoptosis in Hepatocytes

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Cell Engineering

Part of the book series: Cell Engineering ((CEEN,volume 4))

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Conclusions

Enhanced knowledge of the significance of apoptosis in hepatic disease has justified much of the research reviewed in this chapter. Our improved knowledge of the process itself will lend itself to the development of new treatment approaches where therapeutic strategies can be aimed at more specific targets. New therapeutic routes are already being considered in hepatocyte culture and in hepatic disease, with some already in early development. Indeed, several small molecule caspase inhibitors have been undergoing trials for treatment of liver disease (Whelan et al., 2002) and no doubt some will be available soon. Of course the possible targets for such therapy are many in a process so complex.

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Authors and Affiliations

  1. Animal Cell Technology Group, Department of Chemical Engineering, University of Birmingham, Birmingham, UK, B15 2TT

    N. T. Mukwena & Mohamed Al-Rubeai

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  1. N. T. Mukwena
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  2. Mohamed Al-Rubeai
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Editors and Affiliations

  1. School of Chemical Engineering, The University of Birmingham, Edgbaston, Birmingham, UK

    Mohamed Al-Rubeai

  2. Swiss Federal Institute of Technology, Zurich, Switzerland

    Martin Fussenegger

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Mukwena, N.T., Al-Rubeai, M. (2004). Apoptosis in Hepatocytes. In: Al-Rubeai, M., Fussenegger, M. (eds) Cell Engineering. Cell Engineering, vol 4. Springer, Dordrecht. https://doi.org/10.1007/1-4020-2217-4_4

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