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Intrapleural Chemotherapy with and Without Surgery in Malignant Pleural Mesothelioma (MPM)

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Malignant Mesothelioma

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Conclusion and Future Directions

Intrapleural delivery is an effective way of delivering chemotherapy in patients with MPM. Intrapleural chemotherapy can be particularly effective early, when the disease is limited to the pleural surface. However, the current data with the adjuvant intrapleural chemotherapy is inconclusive and should not be routinely used except in the setting of clinical trials. Our results with intrapleural L-NDDP are very encouraging and warrant further studies either as a neoadjuvant or an adjuvant to debulking surgery or in combination with intravenous chemotherapy.

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Author information

Authors and Affiliations

  1. Department of Medicine (Hemato-Oncology), University of Massachusetts Medical School, Fitchburg, MA, USA

    Bilal Piperdi MD

  2. Division of Hematology and Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA

    Dong M. Shin

  3. Department of Oncology, Montefiore Medical Center, Bronx, NY, USA

    Roman Perez-Soler MD

Authors
  1. Bilal Piperdi MD
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  2. Dong M. Shin
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  3. Roman Perez-Soler MD
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Editor information

Editors and Affiliations

  1. Thoracic Oncology, Barbara Ann Karmanos Cancer Institute, Harper University Hospital, USA

    Harvey I. Pass MD (Chief and Professor of Surgery and Oncology) (Chief and Professor of Surgery and Oncology)

  2. Wayne State University School of Medicine, Detroit, MI, 48201, USA

    Harvey I. Pass MD (Chief and Professor of Surgery and Oncology) (Chief and Professor of Surgery and Oncology)

  3. Nevada Cancer Institute, USA

    Nicholas J. Vogelzang MD (Director and Clinical Professor) (Director and Clinical Professor)

  4. Department of Internal Medicine, University of Nevada School of Medicine, Las Vegas, NV, 81935, USA

    Nicholas J. Vogelzang MD (Director and Clinical Professor) (Director and Clinical Professor)

  5. Thoracic Oncology, Cardinal Bernardin Cancer Center, Loyola University Chicago, Stritch School of Medicine, Maywood, IL, 60153, USA

    Michele Carbone MD, PhD (Professor of Pathology, Director) (Professor of Pathology, Director)

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© 2005 Springer Science+Business Media, Inc.

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Piperdi, B., Shin, D.M., Perez-Soler, R. (2005). Intrapleural Chemotherapy with and Without Surgery in Malignant Pleural Mesothelioma (MPM). In: Pass, H.I., Vogelzang, N.J., Carbone, M. (eds) Malignant Mesothelioma. Springer, New York, NY. https://doi.org/10.1007/0-387-28274-2_42

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  • DOI: https://doi.org/10.1007/0-387-28274-2_42

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-22949-2

  • Online ISBN: 978-0-387-28274-9

  • eBook Packages: MedicineMedicine (R0)

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