Regular ArticleStructure and Regulation of the Mouse Melanin-Concentrating Hormone mRNA and Gene
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Melanin-concentrating hormone and immune function
2009, PeptidesDynamic regulation of hypothalamic neuropeptide gene expression and food intake by melanocortin analogues and reversal with melanocortin-4 receptor antagonist
2005, Biochemical and Biophysical Research CommunicationsCitation Excerpt :Indeed, AGRP is the endogenous antagonist of MC3R/4R [24,25], and α-MSH and AGRP are synthesized within an adjacent, but distinct, subgroup of hypothalamic neurons (POMC and AGRP neuron), which are sensitive to input from adiposity-related signals, most notably leptin [25–27]. Melanin-concentrating hormone (MCH), a neuropeptide highly expressed in the lateral hypothalamus (LH), functions as a critical regulator of feeding and energy balance, probably by acting downstream of leptin and the melanocortin system [28,29]. Our present study demonstrated that NPY and AGRP expression is rapidly regulated by the administration of NDP-MSH but also of [Gln6]α-MSH-ND and it is tempting to speculate that [Gln6]α-MSH-ND would regulate dynamically and closely these neuropeptides to respond rapidly to the needs of hypothalamic circuits linked to the control of food intake.
Human immune cells express ppMCH mRNA and functional MCHR1 receptor
2002, FEBS LettersCitation Excerpt :To our knowledge, we present here the first study reporting data demonstrating that MCH and its receptor MCHR1 can act as modulators of the immune system. Previously, the ppMCH and MCHR1 transcripts were observed in tissues like spleen or thymus but not in specific immune cells [9,10]. On base of RT-PCR analysis we showed the presence of the ppMCH and MCHR1 mRNA not only in mouse splenocytes and thymocytes but also in human tonsilar and blood cells.
Chapter II The melanin-concentrating hormone
2002, Handbook of Chemical NeuroanatomyCloning of a novel G protein-coupled receptor, SLT, a subtype of the melanin-concentrating hormone receptor
2001, Biochemical and Biophysical Research Communications