Regular ArticleTumor Cell Endocytosis Imaging Facilitates Delineation of the Glioma–Brain Interface☆
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2014, Pathobiology of Human Disease: A Dynamic Encyclopedia of Disease MechanismsICP-MS analysis of lanthanide-doped nanoparticles as a non-radiative, multiplex approach to quantify biodistribution and blood clearance
2012, BiomaterialsCitation Excerpt :It is possible that investigators wishing to deliver nanoparticles to the endocardium could exploit this effect by infusing positively charged nanoparticles upstream of the chamber of interest (e.g. jugular vein cannulation for right heart delivery). Previous studies have shown that there is a window, roughly between 5 nm and 100 nm, in which nanoparticle blood circulation time and passive tumor delivery by EPR is maximized [15–18]. If the construct is too small, it can be rapidly and efficiently cleared through the kidneys, but if too large (>200 nm), it is efficiently trapped by cells of RES organs [19].
Self-protecting core-shell magnetic nanoparticles for targeted, traceable, long half-life delivery of BCNU to gliomas
2011, BiomaterialsCitation Excerpt :The application of magnetic nanoparticle (MNP) has a number of significant therapeutic implications for drug delivery to brain tumors. First, they are characterized by intrinsic magnetic properties that enable them to act as contrast agents in magnetic resonance imaging (MRI) [25,26] or advanced molecular imaging [27]. In this regard, MNPs are sensitive to external magnetic fields and their concentration can be easily measured.
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Supported in part by NIH 2RO1 CA54886-04A1 and 5RO1CA59649-03, and in part by NIH Grant P41 RR05959. C.Z. was supported by the Deutsche Forschungsgemeinschaft (Zi 477/1-1).