Regular ArticlePharmacokinetics of Intrathecally Applied BDNF and Effects on Spinal Motoneurons
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Brain-derived neurotrophic factor (BDNF) affects the activity of the gonadotrophic axis in sheep
2021, Hormones and BehaviorBDNF-mediated preservation of spiral ganglion cell peripheral processes and axons in comparison to that of their cell bodies
2021, Hearing ResearchCitation Excerpt :Over a course of 8 weeks, the amount of BDNF that could diffuse into the cochlea was calculated to be in the order of 1 ng. In addition, BDNF has a short half-life varying from less than a minute up to 3 h (Poduslo and Gurran, 1996; Dittrich et al., 1996; Sakane and Partridge, 1997; Kishino et al., 2001). Starting with 20 µg BDNF in 200 µl and a flow rate of 0.25 µl/h, ~17 µg BDNF would have been infused into the cochlea after 28 days.
A subpopulation of Bdnf-e1–expressing glutamatergic neurons in the lateral hypothalamus critical for thermogenesis control
2020, Molecular MetabolismCitation Excerpt :Thus, a single injection of the antibody into LH resulted in an increase in Ucp1 expression for as long as 2 weeks (Figure 7F). In contrast, the t1/2 of BDNF is only a few hours [66], and therefore, BDNF needs to be delivered constantly through a cannula implantation of an osmotic pump. Viral expression of BDNF could avoid the short t1/2 problem, but it may elicit some unwanted side effects caused by overexpression and/or activation of its low-affinity receptor p75NTR in addition to TrkB.
TrkB agonistic antibodies superior to BDNF: Utility in treating motoneuron degeneration
2019, Neurobiology of DiseaseTherapeutic potential of a TrkB agonistic antibody for ischemic brain injury
2019, Neurobiology of DiseaseCitation Excerpt :Moreover, a number of studies have reported that intravenous administration of BDNF prior to stroke onset reduced infarct volume and improved functional recovery in animal models of stroke, partially through apoptosis suppression (Schabitz et al., 2000; Zhang and Pardridge, 2001a,b; Schäbitz et al., 2004; Zhang and Pardridge, 2006; Schäbitz et al., 2007; Lu et al., 2016). Despite all the positive modulatory and repair activities of BDNF, its short half-life, minimal tissue penetration (Dittrich et al., 1996), and non-specific activation of p75 neurotrophin receptor (p75NTR) (Kraemer et al., 2014) hinder the development of BDNF as a therapeutic agent against ischemic stroke. Neuronal cell death could be mediated by multiple mechanisms.