Brief CommunicationImplantation of PNS Graft Inhibits the Induction of Neuronal Nitric Oxide Synthase and Enhances the Survival of Spinal Motoneurons Following Root Avulsion
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Brachial Plexus Avulsion: A Model for Axonal Regeneration Study
2015, Neural RegenerationInteractions between the NO-citrulline cycle and brain-derived neurotrophic factor in differentiation of neural stem cells
2012, Journal of Biological ChemistryCitation Excerpt :However, our data show that the lack of NOx production following treatment with l-NAME, MDLA, or 7-Ni, induced p75NTR expression; subsequently NSC became BDNF-responsive. These data are in line with previous studies that relate inhibition of NO expression to the up-regulation of p75NTR expression (55, 56). In summary, we have shown for the first time that AS and NO are directly involved in the progress of NSC differentiation by using an in vitro system, which reflects differentiation conditions occurring in the developing cortex (5).
Differential regulation of neuronal and inducible nitric oxide synthase (NOS) in the spinal cord of mutant SOD1 (G93A) ALS mice
2009, Biochemical and Biophysical Research CommunicationsCitation Excerpt :It has shown that ventral root avulsion in the rat results in the iNOS activation and motor neuronal loss, which is prevented by treatment with NOS inhibitors [21,22]. In this context and others, the neurodestructive effects of NO are mediated by its diffusion limited interaction with superoxide to form the strong oxidant peroxynitrite [21,23,24]. High levels of NO interacting with superoxide form highly toxic peroxynitrite, while low or physiological levels of NO interact with guanylate cyclase to form cGMP which is neuroprotective [24,25].
Cell Grafting for Spinal Cord Injury Repair: Cell Replacement and Bridging Strategies
2007, Cellular Transplantation