Elsevier

Cytokine

Volume 11, Issue 10, October 1999, Pages 729-735
Cytokine

Regular Article
FGF-19, A NOVEL FIBROBLAST GROWTH FACTOR WITH UNIQUE SPECIFICITY FOR FGFR4

https://doi.org/10.1006/cyto.1999.0485Get rights and content

Abstract

We have identified a novel fibroblast growth factor, FGF-19, the most distant member of the FGF family described to date. FGF-19 is a high affinity, heparin dependent ligand for FGFR4 and is the first member of the FGF family to show exclusive binding to FGFR4. Human FGF-19 maps to chromosome 11 q13.1, a region associated with an osteoporosis-pseudoglioma syndrome of skeletal and retinal defects. FGF-19 message is expressed in several tissues including fetal cartilage, skin, and retina, as well as adult gall bladder and is overexpressed in a colon adenocarcinoma cell line.

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    Correspondence to: Austin L. Gurney, Genentech Inc., Department of Molecular Biology MS #37, 1 DNA Way, South San Francisco, CA 94080; E-mail:[email protected]

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