Regular ArticleNon-pertussis Components of Combination Vaccines: Problems with Potency Testing
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Cited by (18)
Animal Refinement and Reduction: Alternative Approaches for Potency Testing of Diphtheria and Tetanus Vaccines
2011, Procedia in VaccinologyDevelopment and use of a novel in vitro assay for testing of diphtheria toxoid in combination vaccines
2009, Journal of Immunological MethodsChildhood and malaria vaccines combined in biodegradable microspheres produce immunity with synergistic interactions
2004, Journal of Controlled ReleaseAn experimental divalent vaccine based on biodegradable microspheres induces protective immunity against tetanus and diphtheria
2003, Journal of Pharmaceutical SciencesCitation Excerpt :Furthermore, the protective efficacy of microsphere-based vaccines has not always been adequately confirmed. Although several investigations2,4–6 have demonstrated the induction of neutralizing antibodies (nAb) and nAb against tetanus and diphtheria toxins generally correlate well with protection in the guinea pig model for currently licensed vaccines,12,13 protective immunity is ideally demonstrated by a direct challenge with the infectious agent. Multivalent vaccines based on slowly degradable microspheres have the potential to improve immunization compliance and coverage, especially in developing countries, and their implementation in vaccine-production strategies is highly attractive.
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