Regular Article
A Hippocampal Protein Associated with Paraneoplastic Neurologic Syndrome and Small Cell Lung Carcinoma

https://doi.org/10.1006/bbrc.1994.1358Get rights and content

Abstract

A hippocampal 38 kd autoantigen recognized by an autoantibody from the serum of a patient with paraneoplastic limbic encephalitis (PLE) and small cell lung carcinoma (SCLC) was isolated by screening a human hippocampal cDNA library. The 1,991-nucleotide ple21 clone was obtained and the deduced 350-residue protein encoded by the ple21 cDNA clone was found to be highly homologous to the neuron-specific RNA recognition motifs (RRMs)-containing proteins. The homologies were confined to the RRMs and the RRM connecting region. The presence of RRM in the antigenic protein may be important in the pathogenesis of SCLC-associated paraneoplastic neurologic syndrome.

References (0)

Cited by (83)

  • Molecular analysis of the HuD gene in neuroendocrine lung cancers

    2010, Lung Cancer
    Citation Excerpt :

    ELAV-like proteins, also called Hu antigens, are a small family of RNA-binding proteins involved in the development and maintenance of nervous system [1–3]. Four ELAV-like proteins have been identified in the genomes of vertebrates, named ELAVL1 (HuR), ELAVL2 (HuB), ELAVL3 (HuC) and ELAVL4 (HuD) [4–7]. HuR is expressed in all tissues examined [8], whereas HuB, HuC and HuD are normally expressed only on terminally differentiated neurons [2,7,9].

  • Peripheral Nerve Antigens

    2005, Peripheral Neuropathy: 2-Volume Set with Expert Consult Basic
View all citing articles on Scopus
View full text