Elsevier

Nitric Oxide

Volume 1, Issue 5, October 1997, Pages 373-385
Nitric Oxide

REVIEW
DNA Damage Induced by Peroxynitrite: Subsequent Biological Effects

https://doi.org/10.1006/niox.1997.0143Get rights and content

Abstract

Nitric oxide (NO) and superoxide rapidly react to yield peroxynitrite. Peroxynitrite is a potent oxidant which reacts with proteins, lipids, and DNA. The present paper overviews the various DNA modifications induced by exposure to peroxynitrite or NO and superoxide concurrently, with special reference to the formation of 8-nitroguanine and 8-oxoguanine as well as the induction of DNA single strand breakage. In addition, we review the secondary processes that may follow the process of DNA damage, such as activation of the nuclear enzyme, poly(ADP-ribose) synthetase, apoptosis, and carcinogenesis.

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      Citation Excerpt :

      For example, NO interacts with superoxide at a similar or even faster rate than the dismutation reaction catalyzed by superoxide dismutase (SOD) and results in the formation of peroxynitrite (ONOO−) [7]. Peroxynitrite has been shown to induce cellular injury through the oxidative modification of DNA, lipids, and proteins [8,9]. The initiation of lipid peroxidation by the action of peroxynitrite appears to play major roles in variety of diseases, as has been suggested for atherosclerosis [10].

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    S. MoncadaJ. StamlerS. GrossE. A. Higgs, Eds.

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