Biomolecules and BiomaterialsSurfactant Effects of Chlorpromazine and Imipramine on Lipid Bilayers Containing Sphingomyelin and Cholesterol
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Cited by (25)
Modulators of cellular cholesterol homeostasis as antiproliferative and model membranes perturbing agents
2023, Biochimica et Biophysica Acta - BiomembranesLipid bilayers: Phase behavior and nanomechanics
2020, Current Topics in MembranesCitation Excerpt :These results are in agreement with recent calorimetric studies of free-standing membranes of the same systems (Mannock et al., 2010). The role of Chol in the structure and nanomechanics of SLBs has been extensively studied by AFM (Adhyapak et al., 2018; Al-Rekabi & Contera, 2018; Garcia-Manyes et al., 2010; Redondo-Morata, Giannotti, & Sanz, 2012b; Sullan et al., 2010), as well as its interplay with sphingolipids or other lipids (Ahyayauch et al., 2002; García-Arribas et al., 2016; Guyomarc'h et al., 2014) and further reviewed in Gumí-Audenis et al. (2016). By means of temperature-controlled AFM imaging and AFM-FS to assess the influence of Chol on the membrane ordering and stability (Redondo-Morata, Giannotti, & Sanz, 2012b), this work analyzed a DPPC:Chol in representative range of compositions up to 50 mol% Chol, studying the phase evolution upon heating (from room temperature to temperatures high above the Tm of DPPC) and the corresponding nanomechanical stability.
Study of rabbit erythrocytes membrane solubilization by sucrose monomyristate using laurdan and phasor analysis
2018, Colloids and Surfaces B: BiointerfacesCitation Excerpt :The actual definition of rafts correspond to structures existing in vivo that are sterol and sphingolipid-enriched, with small size (10–200 nm), heterogeneous and highly dynamic [13]. The solubilization process in bio membranes may be different depending on the state of this structures, in fact, the presence of cholesterol in lipid mixtures makes the bilayers more resistant to solubilization [14], and in equimolar mixtures with phosphatidylcholine, cholesterol decreased the stability of the bilayer towards Triton X-100 [15]. Erythrocytes are the most commonly used model system to study bio membranes due to their relatively simple structure: they lack nuclei and organelles, having only the plasma membrane.
The mechanism of detergent solubilization of lipid bilayers
2013, Biophysical JournalCitation Excerpt :The available information on the temporal order of these observations and on the dependence of temporal order on the physico-chemical properties and concentrations of the lipid and detergent is quite limited. It is known, however, that solubilization is preceded by leakage of entrapped solutes, as indicated by investigations of permeability at subsolubilizing detergent concentrations (61,62). When solubilization is preceded by a lag, the leakage is slow, assuming that detergent equilibration over the two monolayers is a prerequisite to pore formation and solubilization and thus it appears that solubilization occurs only after the bilayer is perforated (29).
Spontaneous vesicles, disks, threadlike and spherical micelles found in the solubilization of DMPC liposomes by the detergent DTAC
2012, Journal of Colloid and Interface ScienceCitation Excerpt :Because bilayer structures (liposomes and disks) were completely solubilized, this D:L range corresponds to stage III of the model [4,5]. Detergents are commonly used for lipid and protein solubilization [41–43], but their study has been mostly limited to obtain critical detergent/lipid ratios at phase boundaries [8,44,45]. Additional work is still required to investigate the effect of detergents on lipids.
Accumulated bending energy elicits neutral sphingomyelinase activity in human red blood cells
2012, Biophysical JournalCitation Excerpt :Detergents (or surfactants) are known to modify the activity of membrane enzymes in various ways (19,20). As shown in Table 1, surfactants of widely different chemical structures, such as CPZ, Na DOC, and lysoPC (all at concentrations well below their critical micellar concentrations to ensure that they would interact with the membrane in the form of monomers (21)) induced SMase activity in RBCs under isotonic conditions to a similar extent as did hypotonic shock (Table 1). PLA2, which cleaves PC (among other phospholipids) to lysoPC and free fatty acids, also induced SMase activity (Table 1).
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