Regular ArticleThioredoxin Reductase Activity Is Decreased by Selenium Deficiency
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The thyroid hormone converting enzyme human deiodinase 1 is inhibited by gold ions from inorganic salts, organic substances, and by small-size nanoparticles
2022, Chemico-Biological InteractionsCitation Excerpt :The mechanism of organic gold(I) derivatives on glutathione peroxidases is based on high affinity of the gold towards the selenolate forming a glutathionate-gold(I)-selenocysteine glutathione complex [19]. The selenoenzyme thioredoxin reductase is inhibited by AUF with a Ki of 4 nM [13] as well as ATG, in vivo and in vitro [20,21]. Human liver microsomes contain a variety of metabolizing enzymes including DIO1 and can be used as an enzyme source for the testing of DIO1 inhibition [22,23].
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2018, Pharmacological ReportsCitation Excerpt :Long-term administration of Se compounds leads to an increase in the cytosolic Se-GPx mRNA in the liver cells, which proves the regulation of these processes at the transcription level [24]. In contrast, in the liver tissues of animals with a Se-deficient diet, TrxR exhibited low activity [15] and long-term supplementation with Se and/or its compounds led to an increase in the activity of hepatic TrxR [25]. The highest increase in the Se-dependent enzyme activity in the liver tissue, after 28 days of Selol 5% supplementation, may be attributed to the increased concentration of Se.
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