Regular ArticleCa2+-Stimulated Mitochondrial Reactive Oxygen Species Generation and Permeability Transition Are Inhibited by Dibucaine or Mg2+
References (34)
- et al.
J. Biol. Chem.
(1993) FEBS Lett.
(1996)FEBS Lett.
(1998)- et al.
Biochim. Biophys. Acta
(1995) - et al.
J. Biol. Chem.
(1990) - et al.
J. Biol. Chem.
(1994) - et al.
Free Radicals Biol. Med.
(1995) - et al.
J. Biol. Chem.
(1996) - et al.
J. Biol. Chem.
(1998) - et al.
Biochim. Biophys. Acta
(1994)
Biochim. Biophys. Acta.
Biochim. Biophys. Acta
Biochem. Biophys. Res. Commun.
J. Biol. Chem.
J. Biol. Chem.
Anal. Biochem.
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To whom correspondence should be addressed. Fax: +55 (19) 788-1118. E-mail:[email protected].
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Present address: Neurosciences Institute, Department of Pharmacology and Neuroscience, University of Dundee, Ninewells Medical School, Dundee DD1 9SY, Scotland, UK.