Regular ArticleAscorbate/Iron Activates Ca2+-Release Channels of Skeletal Sarcoplasmic Reticulum Vesicles Reconstituted in Lipid Bilayers
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Iron catalysis of lipid peroxidation in ferroptosis: Regulated enzymatic or random free radical reaction?
2019, Free Radical Biology and MedicineCitation Excerpt :However, the question of whether Fe-Lb-oxo complexes are formed in cells and contribute to the toxicity of iron remains to be resolved. It should also be mentioned that triggering of lipid peroxidation in ferroptotic cells may be preceded or paralleled by Fe-Ln- or Fe(iv)-Lb-oxo-induced modification of the enzymatic activities of redox-sensitive proteins [125–127]. The nature of the immediate lipid peroxidation products acting as proximate pro-ferroptotic signals still remains to be elucidated.
Identification of cysteines involved in S-nitrosylation, S-glutathionylation, and oxidation to disulfides in ryanodine receptor type 1
2006, Journal of Biological ChemistryLeft Ventricular Systolic Function During Stress Echocardiography Exercise in Subjects With Asymptomatic Hereditary Hemochromatosis
2006, American Journal of CardiologyCitation Excerpt :The mechanisms responsible for the finding are not clear at this point. Experimental studies have shown that iron overload15–17 and increased oxidative stress18,19 can alter ion channels and be associated with cardiac arrhythmias. Further investigation of the clinical relevance and mechanistic considerations of this abnormality is warranted.
ROS in the local and systemic pathogenesis of COPD
2003, Free Radical Biology and MedicineLow N-ethylmaleimide concentrations activate ryanodine receptors by a reversible interaction, not an alkylation of critical thiols
2000, Journal of Biological Chemistry