Regular ArticleSeparation of Freezing- and Drying-Induced Denaturation of Lyophilized Proteins Using Stress-Specific Stabilization: II. Structural Studies Using Infrared Spectroscopy
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2020, Journal of Pharmaceutical SciencesCitation Excerpt :Using these formulations, long-term storage stability (e.g., 18-24 months) may be achieved.12 However, even in the presence of stabilizing disaccharides, lyophilization may result in protein structural perturbations and protein aggregation.13-16 These degradation processes are commonly attributed to freezing-related or dehydration-related stresses imparted during lyophilization.17
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