Communications
Biological Activity of Insulin in Microemulsion in Mice

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Abstract

We have previously studied microemulsions as vehicles for peroral and rectal administration of peptides.1-3 Among the peptides we used, insulin in dogs had a pharmacologic availability of 6.2% when administered po in microemulsion form,4 and 20% when administered rectally in rabbits in the form of a microemulsion gel.5 In all our previous studies, freshly prepared microemulsion was used. In order to examine the stability of peptides in microemulsions, we investigated the potency of insulin in microemulsion according to the USP XXII,e but modified for mice.

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