Research ArticlesControlled Drug Release from Polymeric Delivery Devices II: Differentiation Between Partition-Controlled and Matrix-Controlled Drug Release Mechanisms
REFERENCES (13)
- et al.
J. Pharm. Sci.
(1974) J. Pharm. Sci.
(1963)- et al.
J. Pharm. Sci.
(1970) J. Pharm. Sci.
(1972)- et al.
J. Pharm. Sci.
(1971) - et al.
J. Pharm. Sci.
(1968)
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A Systematic Analysis of the Effect of Extraction Solvents on the Chemical Composition of Extraction Solutions and the Analytical Implications in Extractables and Leachables Studies
2023, Journal of Pharmaceutical and Biomedical AnalysisCitation Excerpt :It is noted that the goal of the discussion is not intended to be a lengthy textbook chapter on migration kinetics and thermodynamics, but to provide a concise and systematic review, analysis, and conceptualization on migration of extractables from materials to solvents and to elucidate the impact of solvents on composition of extraction samples, based on published results and conclusions. It is also pointed out that extractables solubility in solvents play a role in their migration and release for either extraction processes [9]. However, this parameter is convoluted in solvent-material interactions in diffusion and partition coefficients.
In vitro release testing methods for drug-releasing vaginal rings
2019, Journal of Controlled ReleaseCitation Excerpt :For ring devices containing very poorly water-soluble drug molecules, in vitro release testing under sink conditions has been widely reported using solvent/water mixtures. In fact, much of the early research into steroid-releasing vaginal rings made use of highly concentrated aqueous solutions of polyethylene glycol [59–61]. More recently, for vaginal rings releasing highly water-insoluble antiretroviral drugs, alcohol/water mixtures have become common (Boyd et al., 2016; Fetherston et al., 2013b, 2013a; Malcolm et al., 2012b, 2005; McCoy et al., 2017; Murphy et al., 2016).
Progesterone-releasing devices for cattle estrus induction and synchronization: Device optimization to anticipate shorter treatment durations and new device developments
2018, TheriogenologyCitation Excerpt :Release kinetics obeying the Higuchi equation are observed in case diffusion through the depletion layer, which gradually penetrates deeper into the matrix, is rate limiting. A more general equation describing the release from matrix systems is proposed by Chien et al. [54] taking into account the transfer of drug molecules across the interface and through a stagnant diffusion layer in the medium surrounding the device. Without elaborating on the details, the rate of drug transfer from the device to the surrounding medium is affected by drug partitioning i.e. the solubility of the drug in the matrix relative to its solubility in the receiving medium.
The effects of fatty acids in propylene glycol on the percutaneous absorption of alendronate across the excised hairless mouse skin
2008, International Journal of PharmaceuticsIn vitro release of nonoxynol-9 from silicone matrix intravaginal rings
2003, Journal of Controlled ReleaseControlled release of insect sex pheromones from paraffin wax and emulsions
1999, Journal of Controlled Release