TECHNICAL ARTICLES
Effect of Particle Size and Speed of Compaction on Density Changes in Tablets of Crystalline and Spray-Dried Lactose

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Abstract

Tablets were prepared from three particle-size fractions of crystalline and spray-dried lactose by the application of known pressures at a slow speed (upper punch speed 1 mm./min.) and a high speed (upper punch speed 600 mm./min.). The relative volumes and densities of the tablets were determined after ejection from the die and, for the slow speed, under pressure. Changes in volume with load were dependent on the particle size, on the speed of compaction, and on whether the volume was determined at pressure or after release of pressure. Calculation of the mechanism of densification by two different methods showed that particle rearrangement was greatest for the smallest size fraction both at slow and high speeds. Calculation of the yield pressure and the pressure necessary to fill the interparticle void space also was made.

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