Review ArticleThe Binding of Drugs by Plasma Proteins
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2018, Journal of Pharmacological and Toxicological MethodsCitation Excerpt :Serum-containing media also has the potential to skew experiments via drug-protein binding interactions. It is widely known that drugs bind to plasma proteins, especially albumin, and that this binding is expected to reduce free drug concentration (Meyer & Guttman, 1968). Previously, the presence or absence of plasma proteins has been demonstrated to also affect electrical response to drugs in canine Purkinje fiber assays (Limberis et al., 2007).
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