Research Articles
“Crushing-Strength” of Compressed Tablets I: Comparison of Testers

https://doi.org/10.1002/jps.2600570326Get rights and content

By means of a piezo-electric force transducer the actual compressional load exerted at certain scale readings by four types of commercially available “crushing-strength” instruments has been determined. The results indicate that variations in crushing-strength values between instruments are due in part to inaccuracies in instrument scale values, zero errors and varying methods of applying the load. Calibration is therefore necessary for accurate measurements using one instrument or when comparing results from more than one tester.

References (14)

  • C.J. Endicott et al.

    J. Pharm. Sci.

    (1961)
  • A. McCallum et al.

    J. Am. Pharm. Assoc., Sci. Ed.

    (1955)
  • T. Higuchi et al.

    J. Am. Pharm. Assoc., Sci. Ed.

    (1953)
  • K.C. Kwan et al.

    J. Am. Pharm. Assoc., Sci. Ed.

    (1957)
  • E. Nelson

    J. Am. Pharm. Assoc., Sci. Ed.

    (1956)
  • H.J. Fairchild et al.

    J. Pharm. Sci.

    (1961)
  • H. Burlinson et al.

    J. Pharm. Pharmacol.

    (1950)
There are more references available in the full text version of this article.

Cited by (37)

  • Emerging technologies for the non-invasive characterization of physical-mechanical properties of tablets

    2017, International Journal of Pharmaceutics
    Citation Excerpt :

    The test involves subjecting the tablets to a uniform tumbling motion in a drum (friabilator) for a specified period/number of rotations, and measuring the percent weight loss. The externally applied force, which results in the breaking of a tablet in a specific plane is commonly used to analyze the mechanical integrity of tablets (Brook and Marshall, 1968). The USP Chapter on tablet breaking force provides guidelines to analyze the breaking force of tablets.

  • Tensile strengths and hardness of tablets

    1982, Journal of Pharmaceutical Sciences
  • Agglomerate bonding

    1980, Handbook of Powder Technology
View all citing articles on Scopus
View full text