New Instrument and Method for Evaluating Tablet Fracture Resistance
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A critical examination of three-point bending for determining Young's modulus
2022, International Journal of PharmaceuticsCitation Excerpt :Where F is loading force, L is distance between the lower supports, w and h are the width and thickness of the beam, and d is the deflection of beam under F. Three point bending experiments have been extensively used for determining E and tensile strength in pharmaceutical research for more than half of a century (Endicott et al., 1961; Podczeck, 2012; Sun et al., 2018). It also was used as a reference method to validate other methods for E determination (Mazel et al., 2012, 2013; Palomäki et al., 2015).
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2018, International Journal of PharmaceuticsMethods for the practical determination of the mechanical strength of tablets - From empiricism to science
2012, International Journal of PharmaceuticsCitation Excerpt :Furthermore, under the test conditions employed tablets deformed considerably and as a result, small wedges formed at the contact with the loading platens before snapping into four pieces (i.e. two wedges and two halves), or the tablets shattered completely (Shotton and Ganderton, 1960). In 1959 the problems of tablet mechanical strength determination were debated at the US National Industrial Pharmaceutical Conference (First Annual National Industrial Pharmaceutical Research Conference, Land O’Lakes, Wisconsin, June 14–17, 1959; through Endicott et al., 1961) and the common consensus was that the Monsanto and the Strong Cobb hardness tests resulted in numbers without any physical meaning. The conference panel suggested that “a force to break a tablet between the first two fingers and thumb was the most indicative, acceptable and popular method for determining tablet firmness.
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Received October 14, 1960, from the Pharmaceutical Research Dept., New Products Division, Abbott Laboratories, Inc., North Chicago, Ill.
Accepted for publication December 15, 1960.
The authors wish to thank Mr. P. Rinehart of the New Products Division and Mr. E. Krueger of the Control Division for their assistance and counsel.