New Instrument and Method for Evaluating Tablet Fracture Resistance

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Abstract

A new instrument and method for evaluating tablet firmness has been developed and tested. The tablet characteristic measured has been called fracture resistance. Results reported for 19 different tablets show that fracture resistance readings give smaller and more precise results than Strong Cobb hardness.

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Received October 14, 1960, from the Pharmaceutical Research Dept., New Products Division, Abbott Laboratories, Inc., North Chicago, Ill.

Accepted for publication December 15, 1960.

The authors wish to thank Mr. P. Rinehart of the New Products Division and Mr. E. Krueger of the Control Division for their assistance and counsel.

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